Results 1 to 10 of about 188,334 (217)

New therapy of pleural empyema by deoxyribonuclease

Brazilian Journal of Infectious Diseases, 2013
Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics.
Grzegorz Kacprzak, Andrzej Majewski, Jerzy Kolodziej, Adam Rzechonek, Robert Gürlich, Vladimir Bobek   +5 more
doaj   +7 more sources

A tissue-penetrably engineered deoxyribonuclease 1 to prevent nasal polyp formation in chronic rhinosinusitis [PDF]

BMC Pharmacology and Toxicology
Background Neutrophilic chronic rhinosinusitis (CRS) is characterized by persistent inflammation and often responds poorly to corticosteroid therapy. In this disease, neutrophil extracellular traps (NETs) are increasingly recognized as key mediators of ...
Su-Bin Kwak, Roza Khalmuratova, Sang-Jin Kim, Hyun-Woo Shin, Jong-Wan Park   +4 more
doaj   +2 more sources

Extracellular DNA and Deoxyribonuclease Activity as Prognostic Markers in Sepsis [PDF]

Biomedicines
Background/Objectives: Sepsis is characterized by a dysregulated immune response to infection and is associated with high lethality. Extracellular DNA (ecDNA) has drawn significant interest as a damage-associated molecular pattern because of its ...
Monika Janíková, Nikola Pribulová, Katarína Kmeťová, Kristína Macáková, Anna Dobišová, Michaela Kopčová, Mária Bucová, Barbora Vlková, Peter Celec   +8 more
doaj   +2 more sources

Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis [PDF]

JCI Insight
Extracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of ...
Anne Cao Le, Virginie Oudin, Jonathan Dick, Maliha A. Alikhan, Timothy A. Gottschalk, Lu Lu, Kate E. Lawlor, Daniel Koo Yuk Cheong, Mawj Mandwie, Ian E. Alexander, A.R. Kitching, Poh-Yi Gan, Grant J. Logan, Kim M. O’Sullivan   +13 more
doaj   +2 more sources

Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu, Zhiyong Yang, Jinyu Jia, Shijun Zhang, Shengming Huang, Liang Zhang, Min Guan, Guobing Chen, Xinyi Leng, Li’an Huang   +9 more
doaj   +2 more sources

DNA in fresh urine supernatant is not affected by additional centrifugation and is protected against deoxyribonuclease

Molecular and Cellular Probes, 2023
Urinary DNA is widely studied as a non-invasive marker for monitoring of kidneys after transplantation or the progression of urinary tract tumors. The quantity of urinary DNA especially of mitochondrial origin has been reported to mirror kidney damage in
Ľubica Janovičová, Katarína Kmeťová, Ľubomíra Tóthová, Barbora Vlková, Peter Celec   +4 more
doaj   +2 more sources

Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis [PDF]

Journal of Inflammation
Background Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogenesis of RA.
Kristína Macáková, Veronika Borbélyová, Mária Tekeľová, Jakub Janko, Michal Pastorek, Richard Hokša, Norbert Moravanský, Emöke Šteňová, Barbora Vlková, Peter Celec   +9 more
doaj   +2 more sources

Structural and functional characterization of Cas2 of CRISPR-Cas subtype I-C lacking the CRISPR component

Frontiers in Molecular Biosciences, 2022
The genome of pathogenic Leptospira interrogans serovars (Copenhageni and Lai) are predicted to have CRISPR-Cas of subtypes I-B and I-C. Cas2, one of the core Cas proteins, has a crucial role in adaptive defense against foreign nucleic acids.
Vineet Anand, Harshini Sheeja Prabhakaran, Prerana Gogoi, Shankar Prasad Kanaujia, Manish Kumar   +4 more
doaj   +1 more source

Cell-Free Double-Stranded DNA to DNase Ratio Predicts Outcome after Primary Survived Cardiac Arrest

Cells, 2022
(1) Double-stranded DNA (dsDNA) and deoxyribonuclease (DNase) as surrogate parameters for accumulating inflammatory hazards are insufficiently studied in resuscitation research. (2) Blood samples of 76 individuals after CA were analyzed 24 and 96 h after
Richard Rezar, Michael Lichtenauer, Vera Paar, Adrienne Aszlan, Thomas M. Hofbauer, Reinhard Kaufmann, Sarah Wernly, Clemens Seelmaier, Moritz Mirna, Andreas Mangold, Irene M. Lang, Uta C. Hoppe, Anna S. Ondracek, Bernhard Wernly   +13 more
doaj   +1 more source

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Frontiers in Immunology, 2023
Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate.
Mengting Yao, Mengting Yao, Jiacheng Ma, Jiacheng Ma, Dongwen Wu, Dongwen Wu, Chucun Fang, Chucun Fang, Zilong Wang, Zilong Wang, Tianting Guo, Jianwen Mo   +11 more
doaj   +1 more source