Results 1 to 10 of about 101,166 (300)

Extracellular DNA and Deoxyribonuclease Activity as Prognostic Markers in Sepsis [PDF]

Biomedicines
Background/Objectives: Sepsis is characterized by a dysregulated immune response to infection and is associated with high lethality. Extracellular DNA (ecDNA) has drawn significant interest as a damage-associated molecular pattern because of its ...
Monika Janíková, Nikola Pribulová, Katarína Kmeťová, Kristína Macáková, Anna Dobišová, Michaela Kopčová, Mária Bucová, Barbora Vlková, Peter Celec   +8 more
doaj   +2 more sources

Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis [PDF]

JCI Insight
Extracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of ...
Anne Cao Le, Virginie Oudin, Jonathan Dick, Maliha A. Alikhan, Timothy A. Gottschalk, Lu Lu, Kate E. Lawlor, Daniel Koo Yuk Cheong, Mawj Mandwie, Ian E. Alexander, A.R. Kitching, Poh-Yi Gan, Grant J. Logan, Kim M. O’Sullivan   +13 more
doaj   +2 more sources

Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis [PDF]

Journal of Inflammation
Background Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogenesis of RA.
Kristína Macáková, Veronika Borbélyová, Mária Tekeľová, Jakub Janko, Michal Pastorek, Richard Hokša, Norbert Moravanský, Emöke Šteňová, Barbora Vlková, Peter Celec   +9 more
doaj   +2 more sources

Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study

Stroke, 2022
Background: Cell-free DNA (cfDNA) and endogenous deoxyribonuclease activity are opposing mediators and might influence the inflammatory response following acute ischemic stroke.
G. Grosse, Nicole Blume, O. Abu-Fares, F. Götz, Johanna Ernst, A. Leotescu, M. Gabriel, Till van Gemmeren, H. Worthmann, R. Lichtinghagen, Rabea Imker, C. Falk, K. Weissenborn, R. Schuppner, N. de Buhr   +14 more
semanticscholar   +1 more source

Structural and functional characterization of Cas2 of CRISPR-Cas subtype I-C lacking the CRISPR component

Frontiers in Molecular Biosciences, 2022
The genome of pathogenic Leptospira interrogans serovars (Copenhageni and Lai) are predicted to have CRISPR-Cas of subtypes I-B and I-C. Cas2, one of the core Cas proteins, has a crucial role in adaptive defense against foreign nucleic acids.
Vineet Anand, Harshini Sheeja Prabhakaran, Prerana Gogoi, Shankar Prasad Kanaujia, Manish Kumar   +4 more
doaj   +1 more source

Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system

Burns & Trauma, 2021
Background Traumatic injury is associated with increased concentrations of cell-free DNA (cfDNA) in the circulation, which contribute to post-injury complications.
J. Hazeldine, R. Dinsdale, D. Naumann, A. Acharjee, J. Bishop, J. Lord, P. Harrison   +6 more
semanticscholar   +1 more source

Cell-Free Double-Stranded DNA to DNase Ratio Predicts Outcome after Primary Survived Cardiac Arrest

Cells, 2022
(1) Double-stranded DNA (dsDNA) and deoxyribonuclease (DNase) as surrogate parameters for accumulating inflammatory hazards are insufficiently studied in resuscitation research. (2) Blood samples of 76 individuals after CA were analyzed 24 and 96 h after
Richard Rezar, Michael Lichtenauer, Vera Paar, Adrienne Aszlan, Thomas M. Hofbauer, Reinhard Kaufmann, Sarah Wernly, Clemens Seelmaier, Moritz Mirna, Andreas Mangold, Irene M. Lang, Uta C. Hoppe, Anna S. Ondracek, Bernhard Wernly   +13 more
doaj   +1 more source

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Frontiers in Immunology, 2023
Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate.
Mengting Yao, Mengting Yao, Jiacheng Ma, Jiacheng Ma, Dongwen Wu, Dongwen Wu, Chucun Fang, Chucun Fang, Zilong Wang, Zilong Wang, Tianting Guo, Jianwen Mo   +11 more
doaj   +1 more source

Evaluation of HiaureusTM Coagulase Confirmation Kit in Identification of Staphylococcus aureus [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Staphylococcus aureus is a facultative anaerobic Gram positive coccal bacterium whose incidence ranges to different infections. It is a cause of various uncomplicated skin infections, abscesses, septicaemia/bacteraemia, gastroenteritis,
Arunagiri Subramanian, Vidushi K. Chitalia, Kushminda Bangera, Shashikant P. Vaidya, Rajas Warke, Abhay Chowdhary, Ranjana A. Deshmukh   +6 more
doaj   +1 more source

An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis

Drug Delivery, 2023
Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function.
Nan Wang, Jie Ma, Wenxia Song, Chengwu Zhao   +3 more
doaj   +1 more source