Results 11 to 20 of about 202,906 (187)
An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis
Drug Delivery, 2023 Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function.
Nan Wang +3 more
doaj +1 more source
New therapy of pleural empyema by deoxyribonuclease
Brazilian Journal of Infectious Diseases, 2013 Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics.
Grzegorz Kacprzak +5 more
doaj +5 more sources
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
eLife, 2020 Type V CRISPR-Cas interference proteins use a single RuvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential for both bacterial immunity and genome editing.
Joshua C Cofsky +5 more
doaj +1 more source
Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]
, 2013 Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A +6 more
core +8 more sources
Encyclopedia, 2021 The deoxyribonuclease 1 (Dnase1) family is a key family of endonucleases that degrades DNA. Loss of Dnase1 family function causes several diseases where the host’s immune system targets the host, such as systemic lupus erythematosus, hypocomplementemic ...
Minal Engavale +6 more
doaj +1 more source
Bronchopleural communication following intrapleural doses of tPA/DNase for empyema
Respirology Case Reports, 2020 Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is a new treatment for pleural infection. Clinical experiences of tPA/DNase therapy, and its complications, are cumulating.
Bapti Roy +3 more
doaj +1 more source
Pharmacological Activation of cGAS for Cancer Immunotherapy
Frontiers in Immunology, 2021 When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of cancer.
Kyle M. Garland +15 more
doaj +1 more source
Detection of some virulence factors in Pseudomonas aeruginosa associated with diarrhea in Kirkuk City [PDF]
Kirkuk Journal of Science, 2015 Background: studies have shown that Pseudomonas aeruginosa can be a potential cause of antibiotic associated diarrhea. Pathogenesis based on endotoxin, exotoxins, and enzymes.
Siham Sh. AL-Salihi, Abbas Y. Hasan
doaj +1 more source
Deoxyribonuclease activities of rumen bacteria from the genus Prevotella
Acta Agriculturae Slovenica, 1999 Twenty-nine strains belonging to four species of the anaerobic bacterial genus Prevotella were tested for deoxyribonuclease activity against the nonmethylated l phage DNA and circular plasmid pBR322 DNA.
Tomaž ACCETTO, Gorazd AVGUŠTIN
doaj +1 more source
Antioxidants, 2023 Infection with SARS-CoV-2 during pregnancy increases the risk of pregnancy complications associated with inflammation, which could lead to oxidative stress in the placenta. Whether vaccination against COVID-19 has any effect is unclear.
Kristína Macáková +5 more
doaj +1 more source