Results 1 to 10 of about 73,928 (203)

Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis [PDF]

JCI Insight
Extracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of ...
Anne Cao Le, Virginie Oudin, Jonathan Dick, Maliha A. Alikhan, Timothy A. Gottschalk, Lu Lu, Kate E. Lawlor, Daniel Koo Yuk Cheong, Mawj Mandwie, Ian E. Alexander, A.R. Kitching, Poh-Yi Gan, Grant J. Logan, Kim M. O’Sullivan   +13 more
doaj   +3 more sources

Activation of Deoxyribonuclease I by Nicotinamide as a New Strategy to Attenuate Tetracycline-Resistant Biofilms of Cutibacterium acnes [PDF]

Pharmaceutics, 2021
Biofilms of Cutibacterium (C.) acnes (formerly Propionibacterium acnes) are responsible for the persistence and antibiotic resistance of acne vulgaris. In addition to the standard treatments for acne vulgaris, a common adjunctive treatment is the topical
Yi-Hsien Shih, Donald Liu, Yen-Chou Chen, Ming-Hsuan Liao, Woan-Ruoh Lee, Shing-Chuan Shen   +5 more
doaj   +2 more sources

The inhibition of deoxyribonuclease I by hydroxybiphenyls [PDF]

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract DNA extracted with certain commercial brands of phenol is resistant to hydrolysis by the endonuclease deoxyribonuclease I, while DNA extracted with other brands, or prepared by NaCl extraction, is susceptible to hydrolysis. The agent responsible for inhibition has been shown to be an oxidation product produced in some phenols.
Joel Gottesfeld, Nancy H. Adams, A.M. El-Badry, V. Moses, M. Calvin   +4 more
openalex   +5 more sources

Active Site of Deoxyribonuclease I . III. Effects of Radiation on Deoxyribonuclease I in Dry State [PDF]

Journal of Radiation Research, 1963
The mechanisms of inactivation of deoxyribonuclease by direct action of radiation have been studied. By testing kinetic properties of the enzyme and its tryptophan content, it seems likely that when the enzyme molecule absorbs energy from radiation, the energy is transferred to the ‘active site’ of the enzyme.
S. Okada
openalex   +3 more sources

Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis [PDF]

Journal of Inflammation
Background Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogenesis of RA.
Kristína Macáková, Veronika Borbélyová, Mária Tekeľová, Jakub Janko, Michal Pastorek, Richard Hokša, Norbert Moravanský, Emöke Šteňová, Barbora Vlková, Peter Celec   +9 more
doaj   +2 more sources

Crystallization of cytoplasmic actin in complex with deoxyribonuclease I [PDF]

Biochemical Journal, 1985
Crystals of cytoplasmic (porcine liver) actin in complex with deoxyribonuclease I (DNAase I) were prepared for structural determination by X-ray-diffraction analysis. The crystallization of porcine liver actin-DNAase I complex is preceded by a brief treatment with immobilized trypsin, whereby a C-terminal tri- or di-peptide including cysteine-374 is ...
Hans Georg Mannherz, Wolfgang Kabsch, Dietrich Suck, Klaus Friebel, M. Frimmer   +4 more
openalex   +5 more sources

Electrochemical assay for deoxyribonuclease I activity [PDF]

Analytical Biochemistry, 2008
A thiolated oligonucleotide having three ferrocenes was immobilized on a gold electrode through the sulfur-gold linkage. This electrode showed a current response based on the redox reaction of the ferrocene moieties and this response was decreased after treatment with deoxyribonuclease I (DNase I), suggesting the disappearance of the ferrocene moieties
Shinobu Sato, Katsuya Fujita, Masanori Kanazawa, Kosuke Mukumoto, Keiichi Ohtsuka, Michinori Waki, Shigeori Takenaka   +6 more
openalex   +4 more sources

Multifunctional nano-delivery system based on DNase I and photodynamic therapy for combatting enterococcus faecalis biofilm infections [PDF]

Scientific Reports
Persistent or refractory apical periodontitis is primarily caused by microbial retention, as conventional root canal treatment often fails to eliminate infections completely, and systemic antibiotic therapy is insufficient to achieve effective ...
Meng Xia, Shisheng Cao, Zeqi Liu, Jiakang Zhao, Yibo Yuan, Jianhui Ni, Zhengjian Guo, Weihan Wang, Huijuan Yin, Zhaohui Zou   +9 more
doaj   +2 more sources

Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu, Zhiyong Yang, Jinyu Jia, Shijun Zhang, Shengming Huang, Liang Zhang, Min Guan, Guobing Chen, Xinyi Leng, Li’an Huang   +9 more
doaj   +2 more sources

The protective effect of DNase I in retinal vein occlusion [PDF]

Biomolecules & Biomedicine
Retinal vein occlusion (RVO) ranks as the second most prevalent retinal vascular disease, following diabetic retinopathy. Neutrophil extracellular traps (NETs) play an important role in vascular diseases.
Guohua Deng, Xi Zou, Zhinan Liu, Hang Ren, Yanting Li, Bin Chen, Jun Zhang   +6 more
doaj   +2 more sources