Results 1 to 10 of about 170,315 (251)

Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu, Zhiyong Yang, Jinyu Jia, Shijun Zhang, Shengming Huang, Liang Zhang, Min Guan, Guobing Chen, Xinyi Leng, Li’an Huang   +9 more
doaj   +3 more sources

Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis [PDF]

JCI Insight
Extracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of ...
Anne Cao Le, Virginie Oudin, Jonathan Dick, Maliha A. Alikhan, Timothy A. Gottschalk, Lu Lu, Kate E. Lawlor, Daniel Koo Yuk Cheong, Mawj Mandwie, Ian E. Alexander, A.R. Kitching, Poh-Yi Gan, Grant J. Logan, Kim M. O’Sullivan   +13 more
doaj   +4 more sources

Activation of Deoxyribonuclease I by Nicotinamide as a New Strategy to Attenuate Tetracycline-Resistant Biofilms of Cutibacterium acnes [PDF]

Pharmaceutics, 2021
Biofilms of Cutibacterium (C.) acnes (formerly Propionibacterium acnes) are responsible for the persistence and antibiotic resistance of acne vulgaris. In addition to the standard treatments for acne vulgaris, a common adjunctive treatment is the topical
Yi-Hsien Shih, Donald Liu, Yen-Chou Chen, Ming-Hsuan Liao, Woan-Ruoh Lee, Shing-Chuan Shen   +5 more
doaj   +2 more sources

Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis [PDF]

Journal of Inflammation
Background Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogenesis of RA.
Kristína Macáková, Veronika Borbélyová, Mária Tekeľová, Jakub Janko, Michal Pastorek, Richard Hokša, Norbert Moravanský, Emöke Šteňová, Barbora Vlková, Peter Celec   +9 more
doaj   +2 more sources

Extraction and purification of bovine pancreatic Deoxyribonuclease I

مجلة مركز بحوث التقنيات الاحيائية, 2010
Samples of bovine pancreatic and calf thymus glands were collected from local slaughterers to extract deoxyribonuclease I enzyme (DNase I) and DNA respectively.
Baidaa S. Hermiz, Ghazi M. Aziz, Abdel kareem A. Alkazaz   +2 more
doaj   +3 more sources

Deoxyribonuclease I Alleviates Septic Liver Injury in a Rat Model Supported by Venoarterial Extracorporeal Membrane Oxygenation. [PDF]

ASAIO J, 2023
Zhang M, Yan W, Wang T, Pei S, Wang J, Ji B, Wang G.   +6 more
europepmc   +2 more sources

Correction: A fluorescent biosensor for cardiac biomarker myoglobin detection based on carbon dots and deoxyribonuclease I-aided target recycling signal amplification. [PDF]

RSC Adv, 2022
Chen J, Ran F, Chen Q, Luo D, Ma W, Han T, Wang C, Wang C.   +7 more
europepmc   +3 more sources

Impaired deoxyribonuclease I activity in patients with inflammatory bowel diseases. [PDF]

Autoimmune Dis, 2011
Malíčková K, Duricová D, Bortlík M, Hrušková Z, Svobodová B, Machková N, Komárek V, Fučíková T, Janatková I, Zima T, Lukáš M.   +10 more
europepmc   +3 more sources

Multifunctional nano-delivery system based on DNase I and photodynamic therapy for combatting enterococcus faecalis biofilm infections [PDF]

Scientific Reports
Persistent or refractory apical periodontitis is primarily caused by microbial retention, as conventional root canal treatment often fails to eliminate infections completely, and systemic antibiotic therapy is insufficient to achieve effective ...
Meng Xia, Shisheng Cao, Zeqi Liu, Jiakang Zhao, Yibo Yuan, Jianhui Ni, Zhengjian Guo, Weihan Wang, Huijuan Yin, Zhaohui Zou   +9 more
doaj   +2 more sources

Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition [PDF]

Frontiers in Bioengineering and Biotechnology
Deoxyribonuclease I (DNase I) is an enzyme that hydrolyzes the phosphodiester bonds in the DNA backbone, enabling efficient DNA degradation. This activity is particularly relevant for degrading extracellular DNA (eDNA), a key structural component of the ...
Merve Kübra Aktan, Naiera Zayed, Naiera Zayed, Aydan Yadigarli, Manuela Sonja Killian, Rob Lavigne, Wim Teughels, Annabel Braem   +7 more
doaj   +2 more sources