Electrochemical Assay for deoxyribonuclease I Activity [PDF]
Analytical Biochemistry, 2008 A thiolated oligonucleotide having three ferrocenes was immobilized on a gold electrode through the sulfur–gold linkage. This electrode showed a current response based on the redox reaction of the ferrocene moieties and this response was decreased after ...
Fujita, Katsuya +6 more
core +4 more sources
AggregateDiabetic ulcers (DUs), a severe complication of diabetes, are characterized by impaired wound healing and contribute significantly to morbidity and mortality.
Yue Li +15 more
doaj +2 more sources
Neutrophil Extracellular Traps Promote Platelet-Driven Contraction of Inflammatory Blood Clots via Local Generation of Endogenous Thrombin and Softening of the Fibrin Network [PDF]
CellsImmunothrombosis can substantially affect the course and outcomes of severe infections and immune-mediated diseases. While inflammatory thrombi are neutrophil-rich, impact of neutrophils on clot contraction, a key modulator of thrombus stability and ...
Shakhnoza M. Saliakhutdinova +4 more
doaj +2 more sources
Evaluation of the functional effects of genetic variants‒missense and nonsense SNPs, indels and copy number variations‒in the gene encoding human deoxyribonuclease I potentially implicated in autoimmunity. [PDF]
Sci Rep, 2019 Ueki M +8 more
europepmc +3 more sources
Evaluation of all nonsynonymous single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 1, possibly implicated in the blocking of endocytosis-mediated foreign gene transfer. [PDF]
DNA Cell Biol, 2014 Ueki M +5 more
europepmc +3 more sources
Revista Paulista de Pediatria, 2021 Objective: Dornase alfa (rhDNase) reduces the viscosity of purulent sputum in the lungs. The use in patients with cystic fibrosis (CF) is proven. However, the evidence of its applicability to other conditions is limited.
Daniel Meireles +6 more
doaj +2 more sources
A Molecular Dynamics Simulation Study of the Arg206Cys Variant in DNASE1L3 Enzyme
Biology and Life Sciences Forum, 2022 Genome-wide association studies (GWAS) have identified that one of the autoimmune disease-associated loci, predisposing for the development of Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and Systemic Sclerosis (SSc), is the rs35677470 ...
Manio Skarlatou +3 more
doaj +1 more source
Microorganisms, 2023 Pectobacterium carotovorum subsp. carotovorum (Pcc) is known to produce different types of bacteriocins, active protein substances that inhibit or kill related strains and are known to be induced by several factors. In this paper, we report the discovery,
Huang-Pin Wu +4 more
doaj +1 more source
Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]
, 2013 Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A +6 more
core +8 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source