Results 21 to 30 of about 170,315 (251)

Immunothrombosis and Complement Activation Contribute to Disease Severity and Adverse Outcome in COVID-19

Journal of Innate Immunity, 2023
Severe COVID-19 is characterized by systemic inflammation and multiple organ dysfunction syndrome (MODS). Arterial and venous thrombosis are involved in the pathogenesis of MODS and fatality in COVID-19.
Tiphaine Ruggeri, Yasmin De Wit, Noëlia Schärz, Gerard van Mierlo, Anne Angelillo-Scherrer, Justine Brodard, Joerg C. Schefold, Cédric Hirzel, Ilse Jongerius, Sacha Zeerleder   +9 more
doaj   +1 more source

Synthesis and DNase I Inhibitory Properties of New Squaramides

Molecules, 2023
Three new monosquaramides (3a–c) were synthesized, characterized by IR, NMR and X-ray, and evaluated for inhibitory activity against deoxyribonuclease I (DNase I) and xanthine oxidase (XO) in vitro. The target compounds inhibited DNase I with IC50 values
Nina Ruseva, Hristina Sbirkova-Dimitrova, Mariyana Atanasova, Ana Marković, Žaklina Šmelcerović, Andrija Šmelcerović, Adriana Bakalova, Emiliya Cherneva   +7 more
doaj   +1 more source

Deoxyribonuclease I covalently coupled to porous glass [PDF]

FEBS Letters, 1970
A. R. Neurath, Howard H. Weetall
openalex   +4 more sources

Self‐Propelled Proteomotors with Active Cell‐Free mtDNA Clearance for Enhanced Therapy of Sepsis‐Associated Acute Lung Injury

Advanced Science, 2023
Acute lung injury (ALI) is a frequent and serious complication of sepsis with limited therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis‐associated ALI can help develop new therapeutic strategies.
Weichang Huang, Lihong Wen, Hao Tian, Jiamiao Jiang, Meihuan Liu, Yicheng Ye, Junbin Gao, Ruotian Zhang, Fei Wang, Huaan Li, Lihan Shen, Fei Peng, Yingfeng Tu   +12 more
doaj   +1 more source

Deoxyribonuclease Treatment Improves the Homogeneity of Single-Stranded DNA Preparations

BioTechniques, 1997
The isolation of single-stranded (ss) phagemid DNA using standard protocols often results in impure preparations, which contain undesirable quantities of chromosomal and/or double-stranded (ds) phagemid DNA.
T.K. Aliev, A.A. Panina, V.G. Korobko, S.D. Varfolomeyev   +3 more
doaj   +1 more source

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +1 more source

Composite Hydrogel Modulates Intrinsic Immune-Cascade Neovascularization for Ocular Surface Reconstruction after Corneal Chemical Injury

Gels, 2023
Ocular alkali burns recruit neutrophils and triggers neutrophil extracellular trap (NET)-neovascularization cascade effects that limit ocular surface reconstruction and functional repair.
Jun Zhang, Kun Xi, Guohua Deng, Xi Zou, Peirong Lu   +4 more
doaj   +1 more source

Deoxyribonuclease-Positive Staphylococcus epidermidis Strains [PDF]

Applied Microbiology, 1970
Use of the agar plate test for the enzyme deoxyribonucleate 3′-nucleotidohydrolase (deoxyribonuclease) can result in frequent misdiagnosis of Staphylococcus epidermidis as S. aureus.
C H, Zierdt, D W, Golde
openaire   +2 more sources

Studies on Silkworm Deoxyribonuclease I. Part III

Journal of the agricultural chemical society of Japan, 1960
Sp-DNAのS-DNase I消化物のうち約46%は蒸溜水に対して非透析性の所謂“Core”分劃である.本分劃に就いてWyatt(8)の方法によって塩基組成,アデニン:グアニン:シトシン:チミン=29.5:21.5:20.3:28.6 (モル百分率)を求め,又末端燐酸基の定量的除去にボスホモノエステラーゼを用いる事により末端基法によって平均重合度約4.6という値を得,両値から平均分子量約1450を算出した.又S-DNase Iによる分解産物中のモノヌクレオチドが5'-燐酸であるという前報(1)の観察結果を, “Corn”分劃の末端燐酸基の結合位置についても,はぶ毒消化の結果やホスホモノエステラーゼ前処理によるホスホジエステラーゼ感受性の低下から敷衍する事が出来た.欺くてS-DNase ...
Junichiro MUKAI
openalex   +4 more sources

Chronic endometritis. Local prooxidant, antioxidant and immunometabolic disorders. An open-label, prospective, randomized study [PDF]

Гинекология
Aim. To determine local features of lipoperoxidation processes, antioxidant defense, state of matrix metalloproteinases in chronic endometritis. Materials and methods.
Oksana A. Gizinger, Yury A. Sorokin, Viktor E. Radzinskiy   +2 more
doaj   +1 more source