Results 21 to 30 of about 14,183,395 (235)
Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration [PDF]
Journal of NeuroinflammationBackground Deoxyribonuclease 2 (DNase II) is pivotal in the clearance of cytoplasmic double stranded DNA (dsDNA). Its deficiency incurs DNA accumulation in cytoplasm, which is a hallmark of multiple neurodegenerative diseases.
Ling-jie Li +7 more
doaj +2 more sources
Effect of deoxyribonuclease I treatment for dementia in end-stage Alzheimer's disease: a case report. [PDF]
J Med Case Rep, 2016 BackgroundAlzheimer's disease is the most common cause of dementia and is characterized by a progressive loss of brain tissue leading to amyloid-β accumulation and severe decline in cognitive function.
Tetz V, Tetz G.
europepmc +2 more sources
Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort. [PDF]
JNCI Cancer Spectr, 2018 Background Circulating cell-free DNA (cfDNA) is a proposed latent biomarker for several cancers, including liver cancer. Deoxyribonucleases (DNases) facilitate the timely and efficient degradation of cfDNA, leading us to hypothesize that DNase I and/or ...
Golonka RM +7 more
europepmc +2 more sources
Chemistry and Biodiversity, 2021 Deoxyribonuclease I (DNase I) inhibitory properties of two 1‐(pyrrolidin‐2‐yl)propan‐2‐one derivatives were examined in vitro. Determined IC50 values of 1‐[1‐(4‐methoxyphenyl)pyrrolidin‐2‐yl]propan‐2‐one (1) (192.13±16.95 μM) and 1‐[1‐(3,4,5 ...
B. Ilić +5 more
semanticscholar +1 more source
Revista Paulista de Pediatria, 2021 Objective: Dornase alfa (rhDNase) reduces the viscosity of purulent sputum in the lungs. The use in patients with cystic fibrosis (CF) is proven. However, the evidence of its applicability to other conditions is limited.
Daniel Meireles +6 more
doaj +2 more sources
A Molecular Dynamics Simulation Study of the Arg206Cys Variant in DNASE1L3 Enzyme
Biology and Life Sciences Forum, 2022 Genome-wide association studies (GWAS) have identified that one of the autoimmune disease-associated loci, predisposing for the development of Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and Systemic Sclerosis (SSc), is the rs35677470 ...
Manio Skarlatou +3 more
doaj +1 more source
Identification of the functional alleles of the nonsynonymous single-nucleotide polymorphisms potentially implicated in systemic lupus erythematosus in the human deoxyribonuclease I gene. [PDF]
DNA Cell Biol, 2014 Kimura-Kataoka K +6 more
europepmc +2 more sources
Microorganisms, 2023 Pectobacterium carotovorum subsp. carotovorum (Pcc) is known to produce different types of bacteriocins, active protein substances that inhibit or kill related strains and are known to be induced by several factors. In this paper, we report the discovery,
Huang-Pin Wu +4 more
doaj +1 more source
Synthesis and DNase I Inhibitory Properties of New Squaramides
Molecules, 2023 Three new monosquaramides (3a–c) were synthesized, characterized by IR, NMR and X-ray, and evaluated for inhibitory activity against deoxyribonuclease I (DNase I) and xanthine oxidase (XO) in vitro. The target compounds inhibited DNase I with IC50 values
Nina Ruseva +7 more
doaj +1 more source
Journal of Innate Immunity, 2023 Severe COVID-19 is characterized by systemic inflammation and multiple organ dysfunction syndrome (MODS). Arterial and venous thrombosis are involved in the pathogenesis of MODS and fatality in COVID-19.
Tiphaine Ruggeri +9 more
doaj +1 more source