Results 51 to 60 of about 14,183,395 (235)

Early DNase-I therapy delays secondary brain damage after traumatic brain injury in adult mice

Scientific Reports, 2023
Traumatic brain injury (TBI) causes the release of danger-associated molecular patterns (DAMP) from damaged or dead cells, which contribute to secondary brain damage after TBI.
Tobias J. Krämer, Florian Pickart, Bruno Pöttker, Christina Gölz, Axel Neulen, Tobias Pantel, Hermann Goetz, Katharina Ritter, Michael K. E. Schäfer, Serge C. Thal   +9 more
doaj   +1 more source

AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

Molecular Oncology, 2020
Liver metastasis is the main cause of colorectal cancer (CRC)‐related death. Neutrophil extracellular traps (NETs) play important roles in CRC progression.
Yujia Xia, Jiayi He, Hongji Zhang, Han Wang, George Tetz, Casey A. Maguire, Yu Wang, Amblessed Onuma, Dmitry Genkin, Victor Tetz, Alexey Stepanov, Stanislav Terekhov, Valeria Ukrainskaya, Hai Huang, Allan Tsung   +14 more
doaj   +1 more source

Radioprotection by inactivation of deoxyribonuclease I

The FASEB Journal, 2009
Gamma radiation‐induced cell death is associated with and mediated by enzymatic DNA fragmentation. A nuclease that produces this fragmentation of DNA is unknown. To determine whether deoxyribonuclease I (DNase I), a major cytotoxic/apoptotic nuclease expressed in all cells and tissues, can mediate gamma radiation‐induced tissue injury, we used DNase I ...
Yevgeniy O. Apostolov, Alexei G. Basnakian, Osman O. Bagandov, Alena V. Savenka, Richard B. Walker, Izoumroud Soultanova, Xiaoyan Yin, Anna G. Stewart   +7 more
openaire   +2 more sources

Salivary Extracellular DNA and DNase Activity in Periodontitis

Applied Sciences, 2020
Extracellular DNA (ecDNA) is a potential marker and predictor in several inflammatory diseases. Periodontitis, a chronic inflammatory disease, is associated with epithelial cell death and could lead to release of DNA.
Barbora Konečná, Alexandra Gaál Kovalčíková, Alexandra Pančíková, Bohuslav Novák, Eva Kovaľová, Peter Celec, Ľubomíra Tóthová   +6 more
doaj   +1 more source

Systemic Lupus Erythematosus Patients with DNASE1L3·Deficiency Have a Distinctive and Specific Genic Circular DNA Profile in Plasma

Cells, 2023
Cell-free (cf) extrachromosomal circular DNA (eccDNA) has a potential clinical application as a biomarker. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a complex immunological pathogenesis, associated with autoantibody ...
Daniela Gerovska, Marcos J. Araúzo-Bravo   +1 more
doaj   +1 more source

Transcript Identification Using Arrayed Hydrogels With TrapFISH

Advanced Materials Technologies, EarlyView.
TrapFISH is a novel method for high‐throughput single‐cell transcriptomics. It embeds cells in hyaluronic acid hydrogel beads and uses probe hybridization to quantify custom gene panels. By arraying hydrogels in microfluidic devices, cell barcoding is removed, enhancing scalability for studying cellular heterogeneity and rare cell states by targeting ...
David B. Morse, Zenon Toprakcioglu, Akhila Denduluri‐Marthi, James D. Brenton, Craig J. Thomas, Tuomas P. J. Knowles   +5 more
wiley   +1 more source

Deoxyribonuclease-Positive Staphylococcus epidermidis Strains [PDF]

Applied Microbiology, 1970
Use of the agar plate test for the enzyme deoxyribonucleate 3′-nucleotidohydrolase (deoxyribonuclease) can result in frequent misdiagnosis of Staphylococcus epidermidis as S. aureus.
David W. Golde, Charles H. Zierdt
openaire   +3 more sources

Rapid and efficient isolation platform for plasma extracellular vesicles: EV‐FISHER

Journal of Extracellular Vesicles, 2022
Extracellular vesicles (EVs) have found diverse applications in clinical theranostics. However, the current techniques to isolate plasma EVs suffer from burdensome procedures and limited yield.
Wei‐Lun Pan, Jun‐Jie Feng, Ting‐Ting Luo, Yong Tan, Bo Situ, Rienk Nieuwland, Jing‐Yun Guo, Chun‐Chen Liu, Han Zhang, Jing Chen, Wen‐Hua Zhang, Jun Chen, Xian‐Hua Chen, Hong‐Yue Chen, Lei Zheng, Jin‐Xiang Chen, Bo Li   +16 more
doaj   +1 more source

The involvement of NETs in ANCA-associated vasculitis

Frontiers in Immunology, 2023
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a serious autoimmune disease that is characterized by vascular necrosis.
Satoka Shiratori-Aso, Daigo Nakazawa
doaj   +1 more source

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source