Results 181 to 190 of about 10,903 (206)

Depsipeptides Communication 31. Synthesis of depsipeptides containing ?-hydroxy ?-amino acid residues

Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1965
Depsipeptides containing α-hydroxy α-amino acid residues as hydroxy-acid component were synthesized.
G. A. Ravdel', N. A. Krit, V. A. Oladkina, L. A. Shchukina, M. M. Shemyakin   +4 more
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Depsipeptides from Metarhizium anisopliae

Phytochemistry, 1981
Abstract From the culture medium of a strain of Metarhizium anisopliae , 14 depsipeptides have been isolated. Five of them were identified as known destruxins A, B, C, D and desmethyldestruxin B. The structures of the new compounds, named destruxins E, A 1 , A 2 , B 1 , B 2 , C 2 , D 1 , D 2 and E 1 ,were established mainly from the mass spectral ...
Pais, M., Das, B.C., Ferron, P.
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Cyanopeptolins, depsipeptides from cyanobacteria

Systematic and Applied Microbiology, 1996
Summary The wide range of secondary metabolites from cyanobacteria includes cyclic depsipeptides. They can be filed into several classes. Members of class V, the cyanopeptolins, are proposed in this review to be defined as (a) cyanobacterial 19-membered cyclic depsipeptides cyclized by an ester-linkage of the hydroxyl-group of threonine with the ...
Jürgen Weckesser, Cornel Martin, Clemens Jakobi   +2 more
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Fungal cyclooligomer depsipeptides

Natural Product Reports, 2011
This review surveys the biological activities and the iterative and recursive biosynthetic mechanisms of fungal cyclooligomer depsipeptides, and their structural diversification by various combinatorial biosynthetic methods.
Süssmuth, Roderich, Müller, Jane, Von Döhren, Hans, Molnár, István   +3 more
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Total Synthesis of Antitumor Depsipeptide (−)-Doliculide

Organic Letters, 2001
[reaction: see text] (-)-Doliculide, a potent antitumor agent, is synthesized stereoselectively in a convergent manner. The key strategy involves a stereoselective synthesis of the polyketide unit and synthesis of the D-tyrosine derivative, followed by assembly of the fragments by an esterification and cycloamidation reaction sequence. The synthesis of
A K, Ghosh, C, Liu
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Cyclic depsipeptides as potential cancer therapeutics

Anti-Cancer Drugs, 2015
Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki, Genbin, Shi, Shizuka, Miyauchi, Shinya, Murakami, Yili, Yang   +4 more
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Biosynthesis of depsipeptide mycotoxins in Fusarium

European Journal of Plant Pathology, 2002
The cyclic hexadepsipeptide enniatin is known as a phytopathogenic compound from Fusaria causing necrosis and wilt. The molecule consists of three alternating residues each of a branched chain amino acid and D-hydroxyisovaleric acid (D-Hiv). Enniatins are synthesized by a 347kDa multienzyme (enniatin synthetase) via a thiol template mechanism.
Till Hornbogen, Mirko Glinski, Rainer Zocher   +2 more
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The structure-antimicrobial relation of depsipeptides

Experientia, 1963
Die Beziehungen zwischen Struktur und antimikrobieller Aktivitat in der Reihe der Depsipeptide wurden untersucht. Cyclotetradepsipeptide sind praktisch inaktiv. Die grosste Aktivitat besitzen die Cyclohexadepsipeptide mit regularer Oxy- und Aminosaurensequenz.
M M, SHEMYARKIN, Iu A, OVCHINNIKOV, V T, IVANOV, A A, KIRYUSHKIN, G L, ZHDANOV, I D, RYABOVA   +5 more
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Self‐Assembly of Chiral Depsipeptide Dendrimers

Chemistry – A European Journal, 2006
AbstractThe self‐assembly of chiral depsipeptide dendrons 4, which contain a cyanuric acid building block at their focal point, with the homotritopic Hamilton receptor 1 is reported. The 1:3 compositions of the resulting chiral supramolecular dendrimers, the association constants Kn, and the cooperativity of binding expressed by Scatchard plots and the
Kristine, Hager, Alexander, Franz, Andreas, Hirsch   +2 more
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The cyclization of peptides and depsipeptides

Journal of Peptide Science, 2003
AbstractConstricting the peptide backbone into a more defined conformational form through cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the most recent decades. The resulting conformational constraints increase the probability of an optimum response with bio‐receptors.
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