Results 141 to 150 of about 2,772 (159)

The structure-antimicrobial relation of depsipeptides

Experientia, 1963
Die Beziehungen zwischen Struktur und antimikrobieller Aktivitat in der Reihe der Depsipeptide wurden untersucht. Cyclotetradepsipeptide sind praktisch inaktiv. Die grosste Aktivitat besitzen die Cyclohexadepsipeptide mit regularer Oxy- und Aminosaurensequenz.
M M, SHEMYARKIN, Iu A, OVCHINNIKOV, V T, IVANOV, A A, KIRYUSHKIN, G L, ZHDANOV, I D, RYABOVA   +5 more
openaire   +2 more sources

Self‐Assembly of Chiral Depsipeptide Dendrimers

Chemistry – A European Journal, 2006
AbstractThe self‐assembly of chiral depsipeptide dendrons 4, which contain a cyanuric acid building block at their focal point, with the homotritopic Hamilton receptor 1 is reported. The 1:3 compositions of the resulting chiral supramolecular dendrimers, the association constants Kn, and the cooperativity of binding expressed by Scatchard plots and the
Kristine, Hager, Alexander, Franz, Andreas, Hirsch   +2 more
openaire   +2 more sources

The cyclization of peptides and depsipeptides

Journal of Peptide Science, 2003
AbstractConstricting the peptide backbone into a more defined conformational form through cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the most recent decades. The resulting conformational constraints increase the probability of an optimum response with bio‐receptors.
openaire   +2 more sources

Marine Depsipeptides as Promising Pharmacotherapeutic Agents

Current Protein & Peptide Science, 2016
Depsipeptides are a group of biologically active peptides that have at least one of the amide bonds replaced by an ester bond. These peptides sometimes present additional chemical modifications, including unusual amino acid residues in their structures.
Marisa, Rangel, Carlos José Correia, de Santana, Andréia, Pinheiro, Lilian, Dos Anjos, Tania, Barth, Osmindo Rodrigues, Pires, Wagner, Fontes, Mariana S, Castro   +7 more
openaire   +2 more sources

Xentrivalpeptides A–Q: Depsipeptide Diversification in Xenorhabdus

Journal of Natural Products, 2012
Seventeen depsipeptides, xentrivalpeptides A-Q (1-17), have been identified from an entomopathogenic Xenorhabdus sp. Whereas the structure of xentrivalpeptide A (1) was determined after its isolation by NMR spectroscopy and the advanced Marfey's method, the structures of all other derivatives were determined using a combination of stable isotope ...
Zhou, Q., Dowling, A., Heide, H., Wohnert, J., Brandt, U., Brandt, U., Baum, J., Ffrench-Constant, R., Bode, H.B.   +8 more
openaire   +4 more sources

Zur Synthese cyclischer Depsipeptide

Chemische Berichte, 1966
AbstractSynthesen linearer Tetradepsipeptide mit D‐Valin und α‐D‐Hydroxy‐isovaleriansäure als Bausteinen (vom Typ 8 bzw. 11 bzw. 16) werden beschrieben. Die Cyclisierung gelingt nur durch Herstellung einer Amidbindung mittels der Säurechloridmethode, und sie ergibt unter Dimerisierung das Cyclooctadepsipeptid.
openaire   +1 more source

Die Chemie der Depsipeptide

Angewandte Chemie, 1960
AbstractGegenwärtig ist eine bedeutende Anzahl natürlicher Depsipeptide (Verbindungen, die aus ester‐ und amidartig miteinander verknüpften α‐Hydroxy‐ und α‐Aminosäuren bestehen) bekannt. Diejenigen Depsipeptide, deren Konstitution aufgeklärt werden konnte, haben eine cyclische Struktur.
openaire   +1 more source

The structure-antimicrobial relation for valinomycin depsipeptides

Experientia, 1965
Auf Grund eines grossen Vergleichsmaterials wurden die Strukturelemente, die fur die antimikrobielle Aktivitat der Cyclodepsipeptide notig sind, ermittelt. Insbesondere wurden Ringgrosse, Ersatz der Ester- oder N-Methylamid-Gruppe durch eine Amidgruppe, strukturelle und konfigurative Anderung der Aminosaure- und Hydroxysaurereste studiert.
M M, Shemyakin, E I, Vinogradova, M Y, Feigina, N A, Aldanova, N E, Loginova, I D, Ryabova, I A, Pavlenko   +6 more
openaire   +2 more sources

Synthesis of ornithine-containing depsipeptides

Chemistry of Natural Compounds, 1972
The reaction of Nα-benzyloxycarbonyl-Nδ-formyl-L-ornithine with α-hydroxy esters has been studied and conditions have been found under which aminoacylation takes place in high yield.
N. A. Krit, M. P. Filatova, G. A. Ravdel'   +2 more
openaire   +1 more source

The Cyclic Depsipeptide Backbone of the Didemnins

Acta Crystallographica Section C Crystal Structure Communications, 1995
An X-ray crystal analysis of phi-lactone N-¿1-¿N-¿4-¿[3- hydroxy-5-methyl-1-oxo-4-(N-L-threonylamino)heptyl]- oxy¿-2,5-dimethyl-1,3-dioxohexyl¿-L-leucyl¿-L-prolyl¿- N,O-dimethyl-L-tyrosine hydrobromide hydrate (1a), C42H66N5O11+.Br-.H2O, was obtained in order to determine the backbone folding of the macrocycle and to compare the results obtained with ...
S C, Mayer, P J, Carroll, M M, Joullié
openaire   +2 more sources