Advanced Healthcare Materials, Volume 14, Issue 32, December 19, 2025.Meniscal microtissues are fabricated using progenitor cells isolated from the inner (iMPCs) and outer (oMPCs) regions of the meniscus. Meniscal microtissues fuse into cohesive constructs rich in sGAG and collagen. cABC treatment modulates collagen fiber formation and organization in assembled grafts.
Gabriela S. Kronemberger +4 more
wiley +1 more source
Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, Volume 12, Issue 48, December 29, 2025.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
Cancer Innovation, Volume 4, Issue 6, December 2025.Schematic of the methodology applied in this study. Step 1: Gene co‐expression was used to build networks and for enrichment analysis in CRC and villi. Step 2: Identify disordered genes and continuously upregulated/downregulated “off‐track genes” in CRC.
Botao Zhang +6 more
wiley +1 more source
Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan [PDF]
, 2000 It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated.
Bellina, Isabella +11 more
core
Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix [PDF]
, 2016 The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS).
Fernig, David G +5 more
core +1 more source
Sulodexide. Nephroprotective properties and horizons for use in nephrology
Медицинский совет, 2015 Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion ...
M. M. Batyushin
doaj +1 more source
Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]
, 2002 Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core +1 more source
Marine Sourced Glycosaminoglycans ‘GAGs' [PDF]
, 2014 Globally, there is an uprising interest for availability of tangible, novel, added value, sustainable commercial exploitable therapeutic compounds from naturally derived sources.
Ghazali, F. C. (Farid) +2 more
core +2 more sources
Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin. [PDF]
, 2011 OBJECTIVE: Heparan sulfate proteoglycans (HSPGs) modulate the interaction of proangiogenic heparin-binding vascular endothelial growth factors (VEGFs) with signaling VEGF receptor-2 (VEGFR2) and neuropilin coreceptors in endothelial cells (ECs). The bone
Chiodelli P +5 more
core +1 more source
Molecular docking analysis of a dermatan sulfate tetra-saccharide to human alpha-L-iduronidase. [PDF]
Bioinformation, 2023 Durán-Gutiérrez DP +6 more
europepmc +1 more source