Results 101 to 110 of about 18,322 (221)
In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 3, Page 838-852, March 2026.ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini +5 more
wiley +1 more source
Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases
Frontiers in Microbiology, 2019 Glycosaminoglycan (GAG) sulfatases, which catalyze the hydrolysis of sulfate esters from GAGs, belong to a large and conserved sulfatase family. Bacterial GAG sulfatases are essential in the process of sulfur cycling and are useful for the structural ...
Shumin Wang +4 more
doaj +1 more source
Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.This study identified dental and gingival lesions in dairy cattle, revealing the significance of routine periodontal assessment for animal welfare. Decorin levels in GCF samples were compared between healthy and diseased cattle, indicating its potential as a non‐invasive biomarker for dental inflammation.
Nihan AVCI
wiley +1 more source
Assessment of musculoskeletal abnormalities in children with mucopolysaccharidoses using pGALS [PDF]
, 2014 Background - Children with mucopolysaccharidoses (MPS) often have musculoskeletal (MSK) abnormalities. Paediatric Gait, Arms, Legs, and Spine (pGALS), is a simple MSK assessment validated in school-age children to detect abnormal joints.
Chan, Mercedes +7 more
core +2 more sources
Brazilian Journal of Medical and Biological Research, 2003 Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Gozzo A.J. +7 more
doaj
Biomechanical properties of engineered collagen scaffolds [PDF]
, 2005 Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.Includes bibliographical references (leaves 33-35).An experiment was performed to determine the effect of crosslinking on the stiffness of collagen scaffolds ...
Bonebreak, Christina M. (Christina Michelle)
core
Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease. [PDF]
, 2006 The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with various macromolecules, among which are the glycosaminoglycans (GAGs ...
PELOSI P.P. +2 more
core +1 more source
Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]
, 2005 Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross +52 more
core +1 more source
Sulodexide. Nephroprotective properties and horizons for use in nephrology
Медицинский совет, 2015 Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion ...
M. M. Batyushin
doaj +1 more source
Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]
, 2002 Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core +1 more source