Results 81 to 90 of about 10,524 (175)

Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys

Cardiovascular Diabetology, 2004
Background Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and proliferation.
Litwak Kenneth N, Vogl-Willis Catherine A, Wagner Janice D, Edwards Iris J, Cefalu William T   +4 more
doaj   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, Volume 110, Issue 1, Page 125-130, July 2026.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

Influence of Propolis-Containing Nonwoven PLGA Dressings on Dermatan and Chondroitin Sulfate Dynamics During Burn-Wound Healing

Pharmaceuticals
Background/Objectives: Burn wounds are complex injuries associated with extensive inflammation, extracellular matrix (ECM) damage, and a high risk of impaired tissue remodeling and scarring.
Kinga Orlińska, Mateusz Stojko, Jakub Włodarczyk, Janusz Kasperczyk, Oskan Tasinov, Diana Ivanova, Mladena Nikolaeva Radeva, Paweł Janik, Katarzyna Komosińska-Vassev, Krystyna Olczyk, Jerzy Stojko, Paweł Olczyk   +11 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases

Frontiers in Microbiology, 2019
Glycosaminoglycan (GAG) sulfatases, which catalyze the hydrolysis of sulfate esters from GAGs, belong to a large and conserved sulfatase family. Bacterial GAG sulfatases are essential in the process of sulfur cycling and are useful for the structural ...
Shumin Wang, Jingwen Guan, Qingdong Zhang, Xiangxue Chen, Fuchuan Li   +4 more
doaj   +1 more source

Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors

Brazilian Journal of Medical and Biological Research, 2003
Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Gozzo A.J., Nunes V.A., Nader H.B., Dietrich C.P., Carmona A.K., Sampaio M.U., Sampaio C.A.M., Araújo M.S.   +7 more
doaj  

Sulodexide. Nephroprotective properties and horizons for use in nephrology

Медицинский совет, 2015
Sulodexide belongs to the class of glycosaminoglycans (GAGs) or mucopolysaccharides. Found in mammalian tissuesm, GAGs regulate the activity of a wide range of proteins (including chemokines, cytokines, growth factors, enzymes, morphogens, and adhesion ...
M. M. Batyushin
doaj   +1 more source

PERAN HEPARIN DALAM ANGIOGENESIS, EPITELIALISASI DAN PENYEMBUHAN LUKA BAKAR

Saintika Medika, 2012
Heparin was initially used in small doses as an anticoagulant in the treatment of burns. It turned out that in addition to the anticoagulant, heparin in larger doses can be used as an anti-inflammatory, accelerate angiogenesis (Polykratis, et al., 2004),
Ruby Riana Asparini
doaj   +1 more source

Dermatan Sulfate Affects Breast Cancer Cell Function via the Induction of Necroptosis. [PDF]

Cells, 2022
Wisowski G, Pudełko A, Olczyk K, Paul-Samojedny M, Koźma EM.   +4 more
europepmc   +1 more source