Results 81 to 90 of about 11,998 (213)

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, Volume 293, Issue 14, Page 4206-4231, July 2026.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Multistage tandem mass spectrometry of chondroitin sulfate and dermatan sulfate [PDF]

International Journal of Mass Spectrometry, 2011
Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in abundance in extracellular matrices. In connective tissue, CS/DS proteoglycans play structural roles in maintaining viscoelasticity through the large number of immobilized sulfate groups on CS/DS chains. CS/DS chains also bind protein families including growth factors and growth
Alicia M, Bielik, Joseph, Zaia
openaire   +2 more sources

A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides. [PDF]

, 2000
A previously published method for the analysis of glycosaminoglycan disaccharides by high pH anion exchange chromatography (Midura,R.J., Salustri,A., Calabro,A., Yanagishita,M. and Hascall,V.C.
Huckerby, Thomas N., Nieduszynski, Ian A., Lauder, Robert M.   +2 more
core  

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, Volume 293, Issue 13, Page 3848-3864, July 2026.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Brazilian Journal of Medical and Biological Research, 2001
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed.
H.B. Nader, M.A.S. Pinhal, E.C. Baú, R.A.B. Castro, G.F. Medeiros, S.F. Chavante, E.L. Leite, E.S. Trindade, S.K. Shinjo, H.A.O. Rocha, I.L.S. Tersariol, A. Mendes, C.P. Dietrich   +12 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Heparan sulfate and dermatan sulfate derived disaccharides are sensitive markers for newborn screening for mucopolysaccharidoses types I, II and III [PDF]

, 2012
Introduction: Mucopolysaccharidoses (MPSs) are a group of lysosomal storage disorders (LSDs) caused by a defect in the degradation of glycosaminoglycans (GAGs). The accumulation of GAGs in MPS patients results in extensive, severe and progressive disease.
de Ruijter, Jessica, van Vlies, Naomi, Orchard, Paul J, Wagemans, Tom, Orchard, Paul J., de Ru, Minke H, Wijburg, Frits A, de Ru, Minke H., Lund, Allan M., Ijlst, Lodewijk, Schaefer, G. Bradley, Schaefer, G Bradley, Lund, Allan M, Wijburg, Frits A.   +13 more
core   +1 more source

Mucopolysaccharidosis VI

Orphanet Journal of Rare Diseases, 2010
Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease with progressive multisystem involvement, associated with a deficiency of arylsulfatase B leading to the accumulation of dermatan sulfate. Birth prevalence is between 1 in 43,261 and 1 in 1,
Harmatz Paul, Nicely Helen, Valayannopoulos Vassili, Turbeville Sean   +3 more
doaj   +1 more source

Synthesis of a C‐2 Functionalized l‐Iduronic Acid Derivative as a Candidate Pharmacological Chaperone for MPS II (Hunter Syndrome)

Chemistry – An Asian Journal, Volume 21, Issue 11, 15 June 2026.
A C‐2 functionalized l‐iduronic acid derivative was designed and synthesized as a candidate pharmacological chaperone for iduronate‐2‐sulfatase (IDS), the enzyme involved in the lysosomal storage disease MPS II (Hunter syndrome). The synthesis overcomes significant synthetic challenges associated with manipulations of L‐ido scaffolds.
Vaibhavi Nagendra, Shifaza Mohamed, Nicholas W. See, Norbert Wimmer, Daniel Neumann, Paul J. Trim, Marten Snel, Aidan J. Brock, Jack K. Clegg, Neha S. Gandhi, Kim M. Hemsley, Adeline A. Lau, Vito Ferro   +12 more
wiley   +1 more source

Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives [PDF]

, 1996
Carbohydrate Research, 290, 87-96Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY.
VanGorp, C.L., Caldwell, E.E.O., Hansen, K.P., Linhardt, Robert J., Weiler, J.M., Toida, T., Schubert, R.L., Nadkarni, V.D.   +7 more
core   +1 more source