Results 61 to 70 of about 10,524 (175)

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3140-3150, September 2026.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Engineering of Substrate-Binding Domain to Improve Catalytic Activity of Chondroitin B Lyase with Semi-Rational Design

Current Issues in Molecular Biology
Dermatan sulfate and chondroitin sulfate are dietary supplements that can be utilized as prophylactics against thrombus formation. Low-molecular-weight dermatan sulfate (LMWDS) is particularly advantageous due to its high absorbability.
Miao Tian, Yuan-Yuan Xu, Yang-Nan Li, Shen Yu, Yi-Lin Wang, Xiao-Lai Ma, Ye-Wang Zhang   +6 more
doaj   +1 more source

Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction

Brazilian Journal of Medical and Biological Research, 2011
Selectins play an essential role in most inflammatory reactions, mediating the initial leukocyte-rolling event on activated endothelium. Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro.
C.L.R. Belmiro, R.G. Gonçalves, E.O. Kozlowski, A.F. Werneck, C.M. Takyia, M. Leite-Jr., M.S.G. Pavão   +6 more
doaj   +1 more source

Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology. [PDF]

PLoS ONE, 2015
Dermatan sulfate (DS), also known as chondroitin sulfate (CS)-B, is a member of the linear polysaccharides called glycosaminoglycans (GAGs). The expression of CS/DS and DS proteoglycans is increased in several fibrotic renal diseases, including ...
Joost F M Lensen, Johan van der Vlag, Elly M M Versteeg, Jack F M Wetzels, Lambert P W J van den Heuvel, Jo H M Berden, Toin H van Kuppevelt, Angelique L W M M Rops   +7 more
doaj   +1 more source

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

Longitudinal Assessment of Cognitive Development in 23 Patients With Mucopolysaccharidosis (MPS) Type II: Results of up to 14 Years of Follow‐Up

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT This study investigated long‐term cognitive development and genotype–phenotype relationships in patients with Mucopolysaccharidosis Type II (MPS II). A nationwide prospective cohort study was conducted in the Netherlands with cognitive follow‐up since 2007.
J. (Julia) Holdorp, M. E. (Michelle) Kruijshaar, A. A. M. (Audrey) Vollebregt, A. B. (Andre) Rietman, M. R. K. (Marianne) Dijkstra, C. (Carina) Klees, M. (Margreet) Wagenmakers, A. H. P. (Annie) Nguyen, E. (Esmee) Oussoren, A. T. (Ans) van der Ploeg, J. M. P. (Hannerieke) van den Hout   +10 more
wiley   +1 more source

Lipoprotein lipase enhances the interaction of low density lipoproteins with artery-derived extracellular matrix proteoglycans

Journal of Lipid Research, 1993
The association of plasma low density lipoproteins (LDL) with arterial proteoglycans (PG) is of key importance in LDL retention and modification in the artery wall.
IJ Edwards, IJ Goldberg, JS Parks, H Xu, WD Wagner   +4 more
doaj   +1 more source

Unmasking Mucopolysaccharidosis Type I in a Patient With Wolf–Hirschhorn Syndrome: Diagnostic Overshadowing

JIMD Reports, Volume 67, Issue 5, September 2026.
ABSTRACT Mucopolysaccharidosis Type I (MPS I) is a rare lysosomal storage disorder caused by α‐l‐iduronidase deficiency, leading to glycosaminoglycan accumulation and multisystem involvement. Wolf–Hirschhorn Syndrome (WHS) is a chromosomal disorder characterized by growth delay, dysmorphism, and developmental impairment.
Karla Cifuentes‐Uribe, Sandrine Girard, Roseline Froissart, Magali Pettazzoni, Nathalie Guffon   +4 more
wiley   +1 more source

Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems.
Petar D. Petrov, Nuria Granados, Carles Chetrit, Daniel Martínez-Puig, Andreu Palou, M. Luisa Bonet   +5 more
doaj   +1 more source

Multistage tandem mass spectrometry of chondroitin sulfate and dermatan sulfate [PDF]

International Journal of Mass Spectrometry, 2011
Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in abundance in extracellular matrices. In connective tissue, CS/DS proteoglycans play structural roles in maintaining viscoelasticity through the large number of immobilized sulfate groups on CS/DS chains. CS/DS chains also bind protein families including growth factors and growth
Alicia M, Bielik, Joseph, Zaia
openaire   +2 more sources