Results 71 to 80 of about 232,697 (206)

Small Leucine‐Rich Proteoglycans in Cancer: Three Decades of Discovery

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Small leucine‐rich proteoglycans (SLRPs) are a well‐known family of extracellular matrix (ECM) molecules. They consist of five classes with 18 different protein cores originally recognized as having a physically supportive component to the extracellular structure and tissue integrity.
Gabriel J. Pascal, Sadie Kim, Christopher Xie, Maria Danial, Iris Barone, Renato V. Iozzo   +5 more
wiley   +1 more source

Multistage tandem mass spectrometry of chondroitin sulfate and dermatan sulfate [PDF]

International Journal of Mass Spectrometry, 2011
Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in abundance in extracellular matrices. In connective tissue, CS/DS proteoglycans play structural roles in maintaining viscoelasticity through the large number of immobilized sulfate groups on CS/DS chains. CS/DS chains also bind protein families including growth factors and growth
Alicia M, Bielik, Joseph, Zaia
openaire   +2 more sources

Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems.
Petar D. Petrov, Nuria Granados, Carles Chetrit, Daniel Martínez-Puig, Andreu Palou, M. Luisa Bonet   +5 more
doaj   +1 more source

Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology. [PDF]

PLoS ONE, 2015
Dermatan sulfate (DS), also known as chondroitin sulfate (CS)-B, is a member of the linear polysaccharides called glycosaminoglycans (GAGs). The expression of CS/DS and DS proteoglycans is increased in several fibrotic renal diseases, including ...
Joost F M Lensen, Johan van der Vlag, Elly M M Versteeg, Jack F M Wetzels, Lambert P W J van den Heuvel, Jo H M Berden, Toin H van Kuppevelt, Angelique L W M M Rops   +7 more
doaj   +1 more source

Proteoglycans and Lyme Disease: Molecular Interfaces in Adhesion, Tissue Tropism, and Therapeutic Discovery

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Lyme disease, caused by spirochetes of the Borrelia burgdorferi sensu lato complex, is a multisystem tick‐borne infection in which bacterial dissemination depends on interactions with host cells and the extracellular matrix (ECM). Proteoglycans (PGs), composed of core proteins modified with glycosaminoglycan (GAG) chains, are abundant and ...
Fuming Zhang, Ke Xia, Yi‐Pin Lin
wiley   +1 more source

Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives

, 1996
Carbohydrate Research, 290, 87-96Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY.
VanGorp, C.L., Caldwell, E.E.O., Hansen, K.P., Linhardt, Robert J., Weiler, J.M., Toida, T., Schubert, R.L., Nadkarni, V.D.   +7 more
core   +1 more source

Chondroitin / dermatan sulfate modification enzymes in zebrafish development.

PLoS ONE, 2015
Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins.
Judith Habicher, Tatjana Haitina, Inger Eriksson, Katarina Holmborn, Tabea Dierker, Per E Ahlberg, Johan Ledin   +6 more
doaj   +1 more source

Development of a fluorometric microtiter plate-based enzyme assay for arylsulfatase B (MPS VI) using dried blood spots

Molecular Genetics and Metabolism Reports, 2014
Mucopolysaccharidosis type VI or Maroteaux–Lamy syndrome is an autosomal recessive lysosomal storage disorder caused by deficiency of arylsulfatase B (ARS-B) enzyme activity.
Anirudh J. Ullal, David S. Millington, Deeksha S. Bali   +2 more
doaj   +1 more source

Mucopolysaccharidosis type I - Clinical and genetic characteristics of Romanian patients

Romanian Journal of Laboratory Medicine, 2020
Background: Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a deficiency of α-L-iduronidase (IDUA), which leads to the accumulation of partially digested glycosaminoglycans (dermatan sulfate and heparan
Alkhzouz Camelia, Lazea Cecilia, Miclea Diana, Asavoaie Carmen, Nascu Ioana, Pop Tudor, Grigorescu-Sido Paula   +6 more
doaj   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source