Results 91 to 100 of about 18,322 (221)

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Biglycan : a multivalent proteoglycan providing structure and signals [PDF]

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Năstase, Mădălina-Viviana, Schäfer, Liliana, Young, Marian F.   +2 more
core  

Proteoglycans and osteolysis. [PDF]

, 2012
Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss.
A Bruzzaniti, A Corsi, A Irie, A Kumarasuriyar, A-V Rousselle, BA Mosheimer, C Blin-Wakkach, C Damiens, CJ Robinson, D Heymann, E Pivetta, EJ Chang, F Gouin, F Lamoureux, F Lamoureux, F Lézot, H Yasuda, HJ Knowles, J Folwarczna, J Guicheux, JJ Cao, JM Muir, JM Muir, K Chu, K Fuller, K Nakano, K Shinmyouzu, K Yamaguchi, L Duplomb, L Duplomb, L Ling, LA Barbour, LM Haupt, M Baud’huin, M Baud’huin, M Baud’Huin, M Baud’huin, M Presta, P Spessotto, PJ Marie, R Rajgopal, S Georges, S Theoleyre, S Theoleyre, S Théoleyre, SJ Song, SM Cool, SW Fox, T Miyazaki, T Standal, V Kram, W Ariyoshi, WC Raschke, WJ Boyle, WS Simonet, X Jiao, Y Bi, Y Bi, Y Wittrant, YY Kong   +59 more
core   +4 more sources

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Chondroitin Sulfate Proteoglycans Are Associated with the Lesions of Alzheimer\u27s Disease [PDF]

, 1993
Chondroitin sulfate proteoglycans (CSPG) are extracellular matrix proteins inhibitory to neurite outgrowth in vitro and correlated with decreased neurite outgrowth after CNS injury.
Canning, David R., Dewitt, David A., Perry, George, Silver, Jerry   +3 more
core  

Concise Review: Stem/progenitor cell proteoglycans decorated with 7-D-4, 4-C-3, and 3-B-3(-) chondroitin sulfate motifs are morphogenetic markers of tissue development [PDF]

, 2018
This study reviewed the occurrence of chondroitin sulfate (CS) motifs 4‐C‐3, 7‐D‐4, and 3‐B‐3(‐), which are expressed by progenitor cells in tissues undergoing morphogenesis.
Abujarour, Allt, Archer, Arikawa-Hirasawa, Asari, Bakopoulou, Bertoni, Bhatt, Brown, Candela, Canfield, Cano, Caplan, Caterson, Caterson, Caterson, Chen, Collett, Collier, Cortes, Cummings, Dimarino, Doherty, Dowthwaite, Farrugia, Foster, Gama, Ge, Grogan, Guimaraes-Camboa, Guo, Hakomori, Handa, Hayes, Hayes, Hayes, Hayes, Hayes, Hayes, Hayes, Hayes, Hennen, Hidaka, Holley, Jin, Kantor, Kerjaschki, Kishida, Kvist, Leijten, Leung, Mareddy, Matsuzaki, Melrose, Melrose, Melrose, Michalczyk, Mindaye, Muramatsu, Murphy, Nandini, Natunen, Nelson, Ng, Palma, Pomeroy, Pontikoglou, Pufe, Qiu, Roelofs, Rostovskaya, Satomaa, Schuurman, Shu, Shu, Simpson, Smith, Smith, Smith, Solis, Solter, Sorrell, Sorrell, Sorrell, Sorrell, Stepniak, Stimpfel, Sugahara, Toyoda, Turner, Whitelock, Williams, Worthley, Wright, Xie, Yamada, Zeddou, Zhen, Zhou   +98 more
core   +2 more sources

Chondroitinase Versus Papain Digestion Leads to Different Outcome for In Vitro Simulation of Degenerated Discs

JOR SPINE, Volume 9, Issue 1, March 2026.
Chondroitinase ABC and papain similarly alter disc biomechanics and increase injectable volume, but produce fundamentally different structural morphologies. Papain induces cavities, whereas chondroitinase preserves tissue integrity. Hydrogel distributions differ—cloud‐like for chABC, monolithic for papain—supporting chondroitinase as a degeneration and
Jan Ulrich Jansen, Graciosa Quelhas Teixeira, Elias Salzer, Andrea Vernengo, Sibylle Grad, Keita Ito, Cornelia Neidlinger‐Wilke, Hans‐Joachim Wilke   +7 more
wiley   +1 more source

Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys

Cardiovascular Diabetology, 2004
Background Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and proliferation.
Litwak Kenneth N, Vogl-Willis Catherine A, Wagner Janice D, Edwards Iris J, Cefalu William T   +4 more
doaj   +1 more source

Possible role for cell-surface carbohydrate-binding molecules in lymphocyte recirculation. [PDF]

, 1983
We are investigating the hypothesis that carbohydrate-binding molecules on the cell surface are involved in the recirculation of lymphocytes from the bloodstream into lymphoid organs.
Rosen, SD, Stoolman, LM
core   +1 more source

Development of affinity-based delivery of NGF from a chondroitin sulfate biomaterial. [PDF]

, 2011
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Chondroitin sulfate is upregulated at injury, thus methods to promote neurite extension through chondroitin sulfate-rich matrices and
Butterfield, Karen Chao, Conovaloff, Aaron W, Panitch, Alyssa   +2 more
core   +1 more source