Results 41 to 50 of about 5,859,979 (225)

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children

Frontiers in Pediatrics, 2021
Background: The impact of abdominal obesity (AO) on plasma fatty acid changes and cardiometabolic risk in children who are obese and overweight has rarely been investigated.
Man-Chin Hua, Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Ming-Wei Lai, Tsung-Chieh Yao, Tsung-Chieh Yao, Ming-Han Tsai, Ming-Han Tsai, Sui-Ling Liao, Sui-Ling Liao, Shen-Hao Lai, Shen-Hao Lai, Jing-Long Huang, Jing-Long Huang   +14 more
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe [PDF]

, 2003
Recent studies have identified a new family of desaturase-like polypeptide sequences in many higher eukaryotes. Functional characterisation of one member of this family, from Schizosaccharomyces pombe, revealed the enzyme to be a sphingolipid desaturase.
Beale, Michael H., Garton, Sarah, Michaelson, L. V., Napier, Johnathan A., Michael H. Beale, Beaudoin, Frédéric, Sarah Garton, Beale, M. H., Johnathan A. Napier, Michaelson, Louise V., Louise V. Michaelson, Napier, J. A., Frédéric Beaudoin, Beaudoin, F., Garton, S.   +14 more
core   +1 more source

Assay for the terminal enzyme of the stearoyl coenzyme A desaturase system using chick embryo liver microsomes

Journal of Lipid Research, 1977
The NADH-dependent stearoyl CoA desaturase of hepatic microsomes (EC 1.14.99.5) is an enzyme system consisting of cytochrome b5 reductase (EC 1.6.2.2), cytochrome b5, and the terminal desaturase. We have developed a simple method for routine assay of the
V C Joshi, A C Wilson, S J Wakil
doaj   +1 more source

Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health

Lipids in Health and Disease, 2020
Background The aim was to investigate if fatty acid profile and estimated desaturase activities; stearoyl CoA-desaturase (SCD), delta-5-desaturase and delta-6-desaturase (D5D; D6D), differ between individuals with metabolically healthy (MH) and unhealthy
Karianne Svendsen, Thomas Olsen, Tove C. Nordstrand Rusvik, Stine M. Ulven, Kirsten B. Holven, Kjetil Retterstøl, Vibeke H. Telle-Hansen   +6 more
doaj   +1 more source

Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase

Journal of Lipid Research, 2014
Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate.
Obi C. Umunakwe, Adam C. Seegmiller
doaj   +1 more source

Heart rate is associated with markers of fatty acid desaturation: the GOCADAN study [PDF]

International Journal of Circumpolar Health, 2012
Objectives: To determine if heart rate (HR) is associated with desaturation indexes as HR is associated with arrhythmia and sudden death. Study design: A community based cross-sectional study of 1214 Alaskan Inuit. Methods: Data of FA concentrations from
Sven O.E. Ebbesson, Juan C. Lopez-Alvarenga, Peter M. Okin, Richard B. Devereux, Maria Elizabeth Tejero, William S. Harris, Lars O.E. Ebbesson, Jean W. MacCluer, Charlotte Wenger, Sandra Laston, Richard R. Fabsitz, John Kennish, William J. Howard, Barbara V. Howard, Jason Umans, Anthony G. Comuzzie   +15 more
doaj   +1 more source

Revisiting Securidaca longipedunculata Seed Oil: Applying NMR and Mass Spectroscopy to Confirm the Presence of 2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols and Conjugated Hydroxydienoic Fatty Acids

Journal of the American Oil Chemists' Society, EarlyView.
The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith, Jianfeng Zhu, Jin‐Yue Sun   +2 more
wiley   +1 more source

Investigating the potential of dietary iron supplementation to enhance long-chain polyunsaturated fatty acid biosynthesis in Hediste diversicolor

Scientific Reports
Fatty acyl desaturases are nutritionally regulated and depend on iron (Fe) for optimal activity. We hypothesised that dietary Fe supplementation, under conditions promoting desaturase upregulation, can enhance desaturase activity and improve n-3 LC-PUFA ...
Andrea Villena-Rodríguez, Juan C. Navarro, Inmaculada Varó, Felipe Aguado-Giménez, Júlia Pérez-Ara, Myriam Lizanda, Ignacio E. Martín, Inmaculada Rasines, Óscar Monroig   +8 more
doaj   +1 more source