Results 21 to 30 of about 5,859,979 (225)

A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

Lipids in Health and Disease, 2017
Background Genotyping of the rs174547 polymorphism in the fatty acid desaturase 1 gene (FADS1) shows that it is associated with the FA composition of plasma phospholipids and lipid metabolic indices among several ethnic groups.
Huilan Guo, Lichao Zhang, Chaonan Zhu, Fei Yang, Shanshan Wang, Shankuan Zhu, Xiaoguang Ma   +6 more
doaj   +1 more source

A comparative analyses of lipid ratios representing desaturase enzyme activity between preterm and term infants within the first ten weeks of life

Lipids in Health and Disease, 2023
Background Desaturase enzymes play a key role in several pathways including biosynthesis of poly- and mono- unsaturated fatty acids (PUFAs, MUFA). In preterm infants, desaturase enzyme activity (DA) may be a rate-limiting step in maintaining PUFAs levels
Hanis Hidayu Kasim, Laurentya Olga, Stuart Snowden, Eliza Cropp, Albert Koulman, Kathryn Beardsall   +5 more
doaj   +1 more source

Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. [PDF]

, 2006
Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA).
Renaville, B, Mullen, Anne, Anne Mullen, Moloney, F, RENAVILLE, Benedicte France Ghislaine, MOLONEY F, LARONDELLE Y, Helen M. Roche, Molonay, Fiona, Roche, HM, Fiona Moloney, Yvan Larondelle, Mullen, A, Renaville Bénédicte, Moloney, Fiona, Larondelle, Yvan, Yves-Jacques Schneider, MULLEN A, SCHNEIDER YJ ROCHE HM, Roche, Hélèje M., Renaville, Bénédicte, Roche, Helen M, Larondelle, Y, Schneider, Yves-Jacques   +23 more
core   +1 more source

Trans-vaccenate is Δ13-desaturated by FADS3 in rodents

Journal of Lipid Research, 2013
Fatty acid desaturases play critical roles in regulating the biosynthesis of unsaturated fatty acids in all biological kingdoms. As opposed to plants, mammals are so far characterized by the absence of desaturases introducing additional double bonds at ...
Vincent Rioux, Frédérique Pédrono, Hélène Blanchard, Cécile Duby, Nathalie Boulier-Monthéan, Laurence Bernard, Erwan Beauchamp, Daniel Catheline, Philippe Legrand   +8 more
doaj   +1 more source

The alternative pathway C20 Δ8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5-fusion desaturase [PDF]

, 2006
A cDNA encoding a C20 Δ8-desaturase was isolated from the free-living soil amoeba, Acanthamoeba castellanii and functionally characterised by heterologous expression. The open reading frame of the A.
Sayanova, Olga, Sayanova, O. V., Haslam, R. P., Napier, Johnathan A., Lazarus, Colin M., Qi, B., Lazarus, C. M., Lazarus, CM, Napier, JA, Haslam, R, Qi, B, Qi, Baoxiu, Haslam, Richard, Napier, J. A., Sayanova, O   +14 more
core   +1 more source

Metabolic Profiling Reveals an Abnormal Pattern of Serum Fatty Acids in MRL/lpr Mice Under Treatment With Prednisone

Frontiers in Pharmacology, 2020
Glucocorticoids (GCs) are commonly used to treat systemic lupus erythematosus (SLE). Unfortunately, excessive GCs can induce many side effects associated with disordered fatty acid (FA) metabolism.
Qianqian Li, Jia Zhou, Dingyi Zhang, Xiafeng Zhang, Zhenghao Xu, Dehong Wu   +5 more
doaj   +1 more source

Functional characterisation of a Fads2 fatty acyl desaturase with delta6/delta8 activity and an Elovl5 with C16, C18 and C20 elongase activity in the anadromous teleost meagre (Argyrosomus regius) [PDF]

, 2013
The meagre, Argyrosomus regius, is a carnivorous fish with great potential to diversify finfish aquaculture in the Mediterranean. However, currently nothing is known about their essential fatty acid requirements.
Hontoria, Francisco, Navarro, Juan Carlos, Monroig, Oscar, Tocher, Douglas R, Tocher, Douglas R.   +4 more
core   +1 more source

Δ6- and Δ5-desaturase activities in the human fetal liver: kinetic aspects

Journal of Lipid Research, 1998
Δ6- and Δ5-desaturase activities were studied in human fetal liver microsomes obtained after legally approved therapeutic abortion. Enzyme activities were measured by a radiochemical method using reverse-phase high performance liquid chromatography (HPLC)
Annie Rodriguez, Pierre Sarda, Catherine Nessmann, Pierre Boulot, Claude Louis Leger, Bernard Descomps   +5 more
doaj   +1 more source

A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B. [PDF]

PLoS Neglected Tropical Diseases, 2019
BACKGROUND:Leishmania donovani is a protozoan parasite, a primary causative agent of visceral leishmaniasis. Sterol produced via the mevalonate pathway, show differences in composition across biological kingdoms.
Ruby Bansal, Shib Sankar Sen, Rohini Muthuswami, Rentala Madhubala   +3 more
doaj   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources