Results 1 to 10 of about 61,157 (114)

Fatty Acid Profile and Desaturase Activity in Obesity: Roles, Mechanisms, and Clinical Relevance [PDF]

Metabolites
Background: Obesity is a complex metabolic disease associated with several health complications, including insulin resistance, hypertension, and type 2 diabetes mellitus.
Michalina Banaszak, Ilona Górna, Sławomira Drzymała-Czyż   +2 more
doaj   +2 more sources

Tissue-Specific Differences in Fatty Acid Content and Desaturase Activity Between the Liver and Spinal Cord of Diabetic ZDF Rats [PDF]

Biology
Imbalance in fatty acid (FA) metabolism is a critical factor in the development of type 2 diabetes (T2D). This study examined fatty acid composition and desaturase activities in the liver and spinal cord of male Zucker diabetic fatty (ZDF) rats, a ...
Katarína Orešanská, Mária Chomová, Janka Kubincová, Ladislav Turecký, Monika Ďurfinová   +4 more
doaj   +2 more sources

Atherogenic Index of Plasma in Relation to Angiographic Coronary Artery Disease Severity, Plasma Fatty Acid Composition, and Estimated Desaturase Activity: A Cross-Sectional Study [PDF]

Metabolites
Background/Objectives: Conventional lipid parameters incompletely reflect coronary atherosclerotic burden, particularly in the setting of metabolic heterogeneity and residual cardiovascular risk. Composite indices such as the atherogenic index of plasma (
Saime Batirel, Bengu Cetinkaya, Ali Sahin, Tuba Guctekin, Beste Ozben, Mustafa Kursat Tigen   +5 more
doaj   +2 more sources

Determination of FAT-1 desaturase activity and substrate preference [PDF]

Journal of Lipid Research
n-3 PUFAs possess numerous health benefits. The FAT-1 desaturase in the model organism Caenorhabditis elegans is a Δ15-desaturase that converts n-6 PUFAs into n-3 PUFAs.
Xiumei Xu, Yanli Wang, Yao Xu, Yanan Yao, Lin Fu, Shenglin He, Jing Leng, Qun Lu, Xiaoju Zou, Bin Liang   +9 more
doaj   +2 more sources

Soy Consumption, but Not Dairy Consumption, Is Inversely Associated with Fatty Acid Desaturase Activity in Young Adults. [PDF]

Nutrients, 2021
Gonzalez-Soto M, Abdelmagid SA, Ma DWL, El-Sohemy A, Mutch DM.   +4 more
europepmc   +2 more sources

Distinct associations between body mass index and polyunsaturated fatty acids in dementia with Lewy Bodies and Alzheimer’s disease [PDF]

The Journal of Nutrition, Health and Aging
Objective: We aimed to assess the association between body mass index and polyunsaturated fatty acids to determine potential links and metabolic differences between Alzheimer's disease and dementia with Lewy bodies.
Nicolás Castellanos-Perilla, Miguel Germán Borda, Joyce Ruifen Chong, Diego Alejandro Tovar-Rios, Alberto Jaramillo-Jimenez, Rolf K Berge, George E. Barreto, Dag Aarsland, Audun Osland Vik-M   +8 more
doaj   +2 more sources

Complex Interactions Between Circulating Fatty Acid Levels, Desaturase Activities, and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study

Frontiers in Nutrition, 2022
ObjectiveMaternal abnormal fatty acid desaturation has previously been linked to gestational diabetes mellitus (GDM). However, few studies have investigated this relationship longitudinally throughout pregnancy.
Yue Liu, Yue Liu, Yue Liu, Yin-Yin Xia, Yin-Yin Xia, Ting Zhang, Yang Yang, Yang Yang, Richard D. Cannon, Toby Mansell, Toby Mansell, Boris Novakovic, Boris Novakovic, Richard Saffery, Richard Saffery, Ting-Li Han, Ting-Li Han, Ting-Li Han, Hua Zhang, Hua Zhang, Philip N. Baker   +20 more
doaj   +1 more source

Altered fatty acid composition of Nicotiana benthamiana and Nicotiana excelsior leaves under transient overexpression of the cyanobacterial desC gene

Biologia Plantarum, 2020
Transient heterologous gene expression in two model plant species, Nicotiana benthamiana and N. excelsior, has been used to study the localization of the heterologous Δ9 acyl-lipid desaturase (Δ9 desaturase) of Synechococcus vulcanus in different cell ...
M. BERESTOVOY, O.S. PAVLENKO, A.A. TYURIN, E.N. GORSHKOVA, I.V. GOLDENKOVA-PAVLOVA   +4 more
doaj   +1 more source

Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat Δ6-desaturase activity

Journal of Lipid Research, 2004
The Δ6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized.
Hervé Guillou, Sabine D'Andrea, Vincent Rioux, Romain Barnouin, Stéphanie Dalaine, Frédérique Pedrono, Sophie Jan, Philippe Legrand   +7 more
doaj   +1 more source

Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study

Lipids in Health and Disease, 2017
Background Visceral fat accumulation in overweight status has been resulted in changes of fatty acid profiles. The fatty acids profiles can be altered by fatty acid desaturase; the activity of which is highly associated with obesity and other metabolic ...
Miso Kang, Ayoung Lee, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Dong Yeob Shin, Jong Ho Lee   +6 more
doaj   +1 more source