Results 71 to 80 of about 18,623 (291)

Case Report: Autoimmune Pemphigus Vulgaris in a Patient Treated With Cemiplimab for Multiple Locally Advanced Cutaneous Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundPemphigus vulgaris (PV) is a rare and severe autoimmune blistering disorder affecting the skin and mucous membranes, characterized by the production of autoantibodies against two desmosomal adhesion proteins, desmoglein 1 and 3.
Rosalba Buquicchio, Valentina Mastrandrea, Sabino Strippoli, Davide Quaresmini, Michele Guida, Raffaele Filotico   +5 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

The mapping of linear B-cell epitope regions in desmoglein 1 and 3 proteins : Recognition of immobilized peptides by pemphigus patients’ serum autoantibodies [PDF]

, 2013
Desmosomal transmembrane glycoproteins desmoglein 1and desmoglein 3 are targets of life-threatening autoimmune blistering disorders such as Pemphigus vulgaris (PV) and Pemphigus foliaceus(PF).
Bősze, Szilvia, Hudecz, Ferenc, Kárpáti, Sarolta, Silló, Pálma, Szabados, Hajnalka, Uray, Katalin   +5 more
core   +1 more source

Rituximab - Progress but Still Not a Final Resolution for Pemphigus Patients: Clinical Report From a Single Center Study

Frontiers in Immunology, 2022
Pemphigus is a rare autoimmune disease characterized by the production of pathogenic autoantibodies against desmosomal adhesion proteins, desmoglein 1 and 3.
Joško Miše, Ines Lakoš Jukić, Ines Lakoš Jukić, Branka Marinović, Branka Marinović   +4 more
doaj   +1 more source

Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus [PDF]

, 2014
The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous.
Adriana Maria Porro, Amagai M, Amagai M, Amagai M, Amagai M, Amagai M, Anhalt GJ, Anhalt GJ, Arranz D, Asahina A, Barrance VP, Beutner EH, Borradori L, Bruckner AL, Bull RH, Buxton RS, Camisa C, Chan LS, Chan LS, Chorzelski TP, Chorzelski TP, Cozzani E, Cunha PR, Czernik A, DeMento FJ, Duarte IB, Durham A, Düker I, Emmerson RW, Fang Y, Feng SY, Fernandes IC, Floden CH, Fullerton SH, Gengoux P, Gooptu C, Gruss C, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Hashimoto T, Heng A, Hertl M, Hodak E, Horn TD, Hosoda S, Howell SM, Huff JC, Huhn KM, Iida K, Ingber A, Inui S, Ishii K, Ishii N, Jablonska S, Kaplan I, Kimyai-Asadi A, Kitajima Y, Kopp T, Kowalewski C, Kozlowska A, Kubo A, Kubota Y, Laura de Sena Nogueira Maehara, Lebeau S, Leger S, Leithauser LA, Liu Q, Livia de Vasconcelos Nasser Caetano, Lu Y, Lutz ME, Maciejowska E, Maldonado F, Marinovic B, Martel P, Maruyama H, Marzano AV, Mentink LF, Micali G, Miida H, Milvia Maria dos Santos Enokihara, Mimouni D, Mimouni D, Miura T, Miyagawa S, Miyagawa S, Morita E, Morizane S, Moutran R, Müller R, Nakajima K, Nakashima H, Nguyen VT, Nishikawa T, Nousari HC, Nousari HC, O'Toole EA, Ohata C, Ohyama B, Oiso N, Palleschi GM, Patrício P, Prado R, Qian SX, Robinson ND, Ruiz-Genao DP, Sanchez-Palacios C, Santi CG, Santiago-et-Sánchez-Mateos D, Schepens I, Seah PP, Sklavounou A, Sneddon I, Sneddon IB, Szturz P, Tagami H, Taintor AR, Tajima M, Tateishi C, Tsuruta D, Verdier-Sevrain S, Wakahara M, Wallach D, Wallach D, Wang J, Wang J, Weston WL, Yasuda H, Zaraa I, Zaraa I, Zhu X, Zimmermann J   +134 more
core   +4 more sources

Desmoglein Versus Non-desmoglein Signaling in Pemphigus Acantholysis [PDF]

Journal of Biological Chemistry, 2007
Although it is accepted that pemphigus antibody binding to keratinocytes (KCs) evokes an array of intracellular biochemical events resulting in cell detachment and death, the triggering events remain obscure. It has been postulated that the binding of pemphigus vulgaris IgG (PVIgG) to KCs induces "desmosomal" signaling. Because in contrast to integrins
Sergei A. Grando, Alex I. Chernyavsky, Miki Sato-Nagai, Yasuo Kitajima, Juan Arredondo   +4 more
openaire   +3 more sources

Identification of Desmoglein as a Cadherin and Analysis of Desmoglein Domain Structure

Journal of Investigative Dermatology, 2007
In the 1980s and early 1990s, the ability to clone complementary DNA (cDNA) resulted in great advances in cell biology, including our understanding of cell adhesion. Cloning the cDNA encoding desmosomal molecules, and the determination of their deduced amino-acid sequences, provided novel insights into their structure and function. It had been shown by
openaire   +4 more sources

DSG2 (desmoglein 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on DSG2 (desmoglein 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

IgA pemphigus showing IgA antibodies to desmoglein 1 and 3

Dermatology Practical & Conceptual, 2016
Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
Salama Hegazy, Sana Bouchouicha, Aida Khaled, Lilia Laadher, Maryem Kallel Sellami, Faten Zeglaoui   +5 more
doaj   +1 more source

Cortical tension regulates desmosomal morphogenesis

Frontiers in Cell and Developmental Biology, 2022
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch, Jana Schieren, Rudolf E. Leube   +2 more
doaj   +1 more source