Results 31 to 40 of about 8,293 (200)
Cells, 2022 Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
Anna Zakrzewicz +10 more
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Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction [PDF]
Journal of Clinical Investigation, 2005 Autoantibodies against the epidermal desmosomal cadherins desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (PF) and pemphigus vulgaris (PV). It is unknown whether antibody-induced dissociation of keratinocytes is caused by direct inhibition of Dsg1 transinteraction or by ...
Jens, Waschke +4 more
openaire +2 more sources
From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
Frontiers in Immunology, 2022 In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1,
Ning Li +5 more
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, 2010 Review on DSG2 (desmoglein 2), with data on DNA, on the protein encoded, and where the gene is ...
M Yashiro, Yashiro, M
core +1 more source
Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1
Data in Brief, 2016 This data article contains extended, complementary analysis related to the research articles entitled “Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src” (Tsang et al., 2010) [1] and figures related to the review ...
Hong Wan +3 more
doaj +1 more source
Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient [PDF]
Anais Brasileiros de Dermatologia, 2017 : Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3).
Shu Ding +5 more
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Frontiers in Genetics, 2021 Epidermolysis bullosa simplex (EBS) is a blistering dermatosis that is mostly caused by dominant mutations in KRT5 and KRT14. In this study, we investigated one patient with localized recessive EBS caused by novel homozygous c.1474T > C mutations in ...
Fuying Chen +14 more
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Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent
Frontiers in Medicine, 2018 Pemphigus vulgaris lesions have a tendency to localize around natural body orifices. The aim here was to analyze the involvement of nail apparatus in pemphigus vulgaris.
Pawel Pietkiewicz +4 more
doaj +1 more source
Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases
eLife, 2022 IgG4 is the least potent human IgG subclass for the FcγR-mediated antibody effector function. Paradoxically, IgG4 is also the dominant IgG subclass of pathogenic autoantibodies in IgG4-mediated diseases.
Yanxia Bi +11 more
doaj +1 more source
A role for caveolin-1 in desmoglein binding and desmosome dynamics [PDF]
Oncogene, 2011 Desmoglein-2 (Dsg2) is a desmosomal cadherin that is aberrantly expressed in human skin carcinomas. In addition to its well-known role in mediating intercellular desmosomal adhesion, Dsg2 regulates mitogenic signaling that may promote cancer development and progression.
Brennan, D +7 more
openaire +5 more sources