Results 51 to 60 of about 8,293 (200)

The Anti-Desmoglein 1 Autoantibodies in Pemphigus Vulgaris Sera are Pathogenic

, 1999
Pemphigus vulgaris and pemphigus foliaceus are two closely related, but clinically and histologically distinct, autoimmune skin diseases. The autoantigens for pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively. The
Ding, Xiang, Liu, Zhi, Giudice, George J., Fairley, Janet A., Diaz, Luis A.   +4 more
core   +1 more source

Diagnostic Utility of BIOCHIP Mosaic Indirect Immunofluorescence in Intraepidermal Autoimmune Blistering Diseases

Clinical Dermatology Review
Background: Pemphigus is a chronic intraepidermal autoimmune blistering disorder (IABD) characterized by the presence of circulating autoantibodies against desmogleins 1and 3.
Padmini Chitradurga Vijayasarathy, Rajalakshmi Tirumalae   +1 more
doaj   +1 more source

Innate immune activation as cofactor in pemphigus disease manifestation

Frontiers in Immunology, 2022
Molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris are subject of current research to date. To decipher the discrepancy between ubiquitous antibody binding to the epidermal desmosomes, but discontinuous disease ...
Ramona A. Eichkorn, Morna F. Schmidt, Elias Walter, Michael Hertl, Jens Malte Baron, Jens Waschke, Amir S. Yazdi, Amir S. Yazdi   +7 more
doaj   +1 more source

Paraneoplastic pemphigus without antibodies to desmoglein 1 and [PDF]

Dermatology Online Journal, 2018
Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions ...
Flood, Kelsey, Stroud, Christopher, Lazarov, Zelmira, Vigneswara, Nadarajah, Hsu, Sylvia   +4 more
openaire   +3 more sources

Proteomic definition of a desmoglein linear determinant common to Pemphigus vulgaris and Pemphigus foliaceous

Journal of Translational Medicine, 2006
Background A number of autoimmune diseases have been clinically and pathologically characterized. In contrast, target antigens have been identified only in a few cases and, in these few cases, the knowledge of the exact epitopic antigenic sequence is ...
Sinha Animesh A, Serpico Rosario, Tessitore Luciana, Mittelman Abraham, Lucchese Alberta, Kanduc Darja   +5 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Circulating Antibodies Against DSG1 and DSG3 in Patients with Oral Lichen Planus: A Scoping Review

Antibodies
Oral Lichen Planus (OLP) is a chronic autoimmune disease with potential overlap with Pemphigus Vulgaris (PV), particularly in erosive forms. Desmoglein 1 and 3 are transmembrane glycoproteins of desmosomes, typically involved in PV.
Domenico De Falco, Francesca Iaquinta, Doriana Pedone, Alberta Lucchese, Dario Di Stasio, Massimo Petruzzi   +5 more
doaj   +1 more source

Implications of normal and disordered remodeling dynamics of corneodesmosomes in stratum corneum

Dermatologica Sinica, 2015
Desmosomes and corneodesmosomes are the most important adhering junctions, providing strength for the epidermal sheet structure made of living keratinocytes and enucleated stratum corneum corneocytes, respectively.
Yasuo Kitajima
doaj   +1 more source

Pemfigus Vulgaris: Laporan Kasus (Pemphigus vulgaris after covid-19 vaccine: association or coincidence?)

JKS (Jurnal Kedokteran Syiah Kuala), 2022
karena produksi autoantibodi terhadap protein desmosomal kulit, yaitu desmoglein (Dsg) 1 dan desmoglein 1 Dsg3. Beberapa faktor termasuk kerentanan genetik, obat-obatan tertentu dan keganasan telah dilaporkan memicu atau memperburuk PV.
Nanda Earlia, Mimi Maulida, Vella Vella, Mikyal Bulqiah, Aqil Yuniawan Tasrif, Aulia Aulia   +5 more
doaj   +1 more source

Cyclophosphamide is associated with long‐term treatment‐free remission in patients with pemphigus

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objective Pemphigus treatment has seen significant advancements, yet long‐term remission remains a challenge. Comparative data on the long‐term effectiveness of available therapies are limited. We compared 10‐year relapse rates in pemphigus patients treated with azathioprine or cyclophosphamide plus high‐dose IV corticosteroids ...
Bettina Santler, Simon Lüdtke, Lena Dietze, Marie Schiffmann, Dominik Straube, Jan Ehrchen   +5 more
wiley   +1 more source