Results 71 to 80 of about 29,699,951 (159)
Dermatology ReportsIntroduction. Pemphigus vulgaris (PV) is an autoimmune blistering disease driven by IgG autoantibodies against desmoglein (Dsg) 1 and 3. Rare fulminant variants may mimic Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).
Associazione Dermatologi-Venereologi Ospedalieri Italiani e della Sanità Pubblica
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MedComm, Volume 7, Issue 9, September 2026.This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu +12 more
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Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function.
, 2014 AIMS: We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is ...
Syrris, P +20 more
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Nano Select, Volume 7, Issue 9, September 2026.Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian +7 more
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Desmoglein 1 in ovine muzzle skin detected by immunohistochemistryand immunoblotting [PDF]
, 2005 SUMMARY Desmosomes are epithelial adhesion structures that assure the mechanical cell-cell adhesion, by linking the intermediate filaments of two adjacent cells.
Miragliotta, Vincenzo +6 more
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Journal of Indian Academy of Oral Medicine and RadiologyBackground: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi +4 more
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American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg +9 more
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A Case Report of a Patient With Recalcitrant Pemphigus Vulgaris Treated With Rituximab
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Pemphigus vulgaris may demonstrate differential treatment responses across disease sites. In this case, cutaneous lesions responded to high‐dose corticosteroids, whereas refractory oral disease required rituximab to achieve remission, highlighting the need for individualized, multimodal therapy to achieve sustained disease control.
Mahlatse Cordelia Kgokolo +3 more
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Phenotypic alteration of basal cells in oral lichen planus; switching keratin 19 and desmoglein 1 expression [PDF]
, 2018 application/pdfIn oral lichen planus, extracellular matrix and basal cells are damaged by T-lymphocytes. As a consequence, changes in expression of collagen fibers within the connective tissue and cytoskeletons of the epithelial tissue can be observed ...
Shimada, Katsumitsu +7 more
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T Lymphocytes from a Subset of Patients with Pemphigus Vulgaris Respond to Both Desmoglein-3 and Desmoglein-1 [PDF]
, 1997 Pemphigus vulgaris and pemphigus foliaceus are cutaneous autoimmune diseases characterized by intraepithelial blisters and autoantibodies to desmosomal glycoproteins.
Lin, Mong-Shang +5 more
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