Results 21 to 30 of about 8,293 (200)

Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus

Veterinary Immunology and Immunopathology, 2006
The majority of human patients with pemphigus foliaceus (PF) have circulating IgG autoantibodies that target conformational epitopes on the desmosomal cadherin desmoglein-1 (dsg1). Limited studies using immunoblot techniques suggested that the principal autoantigen in dogs with PF might also be dsg1.
Olivry, Thierry, LaVoy, Alora, Dunston, Stanley M, Brown, Rachel S, Lennon, Elizabeth M, Warren, Simon J, Prisayanh, Phillip, Müller, Eliane Jasmine, Suter, Maja, Dean, Gregg A   +9 more
openaire   +4 more sources

Desmoglein-1, differentiation, and disease. [PDF]

J Clin Invest, 2013
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
Hammers CM, Stanley JR.
europepmc   +4 more sources

Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris: correlation with disease severity. [PDF]

J Clin Exp Dent, 2020
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes caused by autoantibodies against desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Pemphigus vulgaris (PV) is the most common form of pemphigus. The aim of this study was to assess
Delavarian Z, Layegh P, Pakfetrat A, Zarghi N, Khorashadizadeh M, Ghazi A.   +5 more
europepmc   +2 more sources

Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]

Archives of Dermatology, 1999
To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
K, Ishii, M, Amagai, A, Komai, T, Ebihara, T P, Chorzelski, S, Jablonska, K, Ohya, T, Nishikawa, T, Hashimoto   +8 more
openaire   +2 more sources

Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study

Van Tıp Dergisi, 2021
INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın, Ayşe Mine Gök, Tuğba Kevser Uzunçakmak, Zekayi Kutlubay   +3 more
doaj   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Pemphigus IgG Causes Skin Splitting in the Presence of Both Desmoglein 1 and Desmoglein 3 [PDF]

The American Journal of Pathology, 2007
According to the desmoglein (Dsg) compensation concept, different epidermal cleavage planes observed in pemphigus vulgaris and pemphigus foliaceus have been proposed to be caused by different autoantibody profiles against the desmosomal proteins Dsg 1 and Dsg 3.
Volker, Spindler, Detlev, Drenckhahn, Detlef, Zillikens, Jens, Waschke   +3 more
openaire   +2 more sources

The value of trichoscopy in the differential diagnosis of scalp lesions in pemphigus vulgaris and pemphigus foliaceus [PDF]

Anais Brasileiros de Dermatologia, 2014
BACKGROUND: Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease.
Marta Sar-Pomian, Marta Kurzeja, Lidia Rudnicka, Malgorzata Olszewska   +3 more
doaj   +2 more sources

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Bettina Kempf, Partilla, Miriam, Jens Waschke, Hartlieb, Eva, Waschke, Jens, Kempf, Bettina, Eva Hartlieb (103934), Vigh, Balázs, Miriam Partilla, Miriam Partilla (103942), Balázs Vigh, Bettina Kempf (103938), Eva Hartlieb, Volker Spindler (103952), Balázs Vigh (103947), Jens Waschke (103956), Spindler, Volker, Volker Spindler   +17 more
core   +1 more source

Rituximab in pemphigus foliaceous with autoantibodies against both Desmoglein 1 and Desmoglein 3 [PDF]

European Journal of Dermatology, 2011
ejd.2011.1288 Auteur(s) : Rodrigo CARVALHO1 rodrigoaraujocarvalho@gmail.com, Paula MAIO1, Daniela CUNHA1, Isabel FREITAS1, Ana AFONSO2, Jorge CARDOSO1 1 Department of Dermatology and Venereology, Curry Cabral Hospital, Lisbon, Portugal 2 Department of Pathology, Curry Cabral Hospital, Lisbon, Portugal Reprints.: R. CARVALHO Pemphigus foliaceous (PF) is
Rodrigo CARVALHO, Paula MAIO, Daniela CUNHA, Isabel FREITAS, Ana AFONSO, Jorge CARDOSO   +5 more
openaire   +1 more source