Results 11 to 20 of about 8,293 (200)

Investigation of SNPs in the porcine desmoglein 1 gene [PDF]

BMC Veterinary Research, 2007
Background Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S.
Andresen Lars, Daugaard Lise, Fredholm Merete   +2 more
doaj   +6 more sources

Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus. To validate this hypothesis genetically, we used desmoglein-3 knockout mice (DSG3-/-) that lose their telogen hair ...
Hanakawa, Yasushi, Matsuyoshi, Norihisa, Stanley, John R.   +2 more
openaire   +3 more sources

Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up [PDF]

Clinical and Developmental Immunology, 2009
The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni-Fortina, Diana Faggion, Barbara Pigozzi, Andrea Peserico, Matteo Bordignon, Vincenzo Baldo, Mauro Alaibac   +6 more
doaj   +3 more sources

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

Advanced Biomedical Research, 2016
Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis.
Fariba Iraji, Nabet Tajmirriahi, Iman Momeni, Kioumars Jamshidi, Fazlollah Hashemzehi, Amir Hossein Siadat, Alireza Asemi Esfahani   +6 more
doaj   +2 more sources

Epithelial barrier dysfunction in desmoglein-1 deficiency. [PDF]

J Allergy Clin Immunol, 2018
Mutations in the desmoplakin (DSP) and desmoglein-1 (DSG1) genes have been implicated in patients with the inherited inflammatory skin disease known as severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome (MIM#603165, see Tables E1 and E2 in this article's Online Repository at www.jacionline.org).1, 2 The DSP and DSG1 genes ...
Polivka L, Hadj-Rabia S, Bal E, Leclerc-Mercier S, Madrange M, Hamel Y, Bonnet D, Mallet S, Lepidi H, Ovaert C, Barbet P, Dupont C, Neven B, Munnich A, Godsel LM, Campeotto F, Weil R, Laplantine E, Marchetto S, Borg JP, Weis WI, Casanova JL, Puel A, Green KJ, Bodemer C, Smahi A.   +25 more
europepmc   +6 more sources

ELISA detection of anti‐desmoglein 1 and anti‐desmoglein 3 and indirect immunofluorescence in oral pemphigus: A retrospective study

Oral Diseases, 2021
Abstract Objective The aim of this study was to test the efficacy of autoantibodies to desmoglein 1 and desmoglein 3 detected by ELISA and indirect immunofluorescence in the diagnosis of oral pemphigus and to correlate the antibody titres with the severity of the disease.
Massimo Petruzzi, Alberta Lucchese, Maria Contaldo, Marilina Tampoia, Maria Antonia Frassanito, Dorina Lauritano, Fedora della Vella   +6 more
core   +6 more sources

Long-lasting localized pemphigus vulgaris without detectable serum autoantibodies against desmoglein 3 and desmoglein 1

Indian Journal of Dermatology, 2016
Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area.
Asuka Yoshifuku, Kazuyasu Fujii, Hisao Kawahira, Hiromi Katsue, Atsunori Baba, Yuko Higashi, Yumi Aoyama, Takuro Kanekura   +7 more
doaj   +3 more sources

A Systematic Review on the Role of Desmoglein 1 and Desmoglein 3 in Etiopathogenesis and Metastasis of Oral Cancer

Journal of Indian Academy of Oral Medicine and Radiology
Background: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Gandikota Raghurama Rao, Sandhya Pavankumar, Divya Uppala   +4 more
doaj   +2 more sources

Desmoglein ELISA in the Diagnosis of Pemphigus and Its Correlation with the Severity of Pemphigus Vulgaris

Iranian Journal of Allergy, Asthma and Immunology, 2009
Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigus diseases. Our objective was to assess the value of ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris.
Mortazavi Hossein, Shahdi Majid , Amirzargar Ali Akbar , S.Naraghi Zahra, Valikhani Mahin , Daneshpazhooh Maryam, Vasheghani-Farahani Amir, Sedaghat Mojtaba, Chams-Davatchi Cheyda   +8 more
doaj   +2 more sources

T Lymphocytes from a Subset of Patients with Pemphigus Vulgaris Respond to Both Desmoglein-3 and Desmoglein-1

Journal of Investigative Dermatology, 1997
Pemphigus vulgaris and pemphigus foliaceus are cutaneous autoimmune diseases characterized by intraepithelial blisters and autoantibodies to desmosomal glycoproteins. The antigens recognized by pemphigus vulgaris and pemphigus foliaceus autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.
Lin, Mong-Shang, Swartz, Sue J., Lopez, Argelia, Ding, Xiang, Fairley, Janet A., Diaz, Luis A.   +5 more
openaire   +3 more sources