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Current Opinion in Cell Biology, 1993
Desmosomes and hemidesmosomes are extremely different in their molecular composition. Most of the protein and glycoprotein components are products of members of multigene families, but show specialization for plaque formation and intermediate filament attachment.
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Desmosomes and hemidesmosomes are extremely different in their molecular composition. Most of the protein and glycoprotein components are products of members of multigene families, but show specialization for plaque formation and intermediate filament attachment.
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Journal of Cell Science
ABSTRACT Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate filament cytoskeleton to cell–cell junctions.
Abbey L. Perl +2 more
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ABSTRACT Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate filament cytoskeleton to cell–cell junctions.
Abbey L. Perl +2 more
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Discriminating roles of desmosomal cadherins: Beyond desmosomal adhesion
Journal of Dermatological Science, 2007The desmosomal cadherins, which include desmogleins and desmocollins, are Ca(2+)-dependent adhesion molecules that cooperate to make up the adhesive core of intercellular junctions known as desmosomes. The roles of desmosomal cadherins in epidermal integrity and as targets in human cutaneous disease have been well established.
Rachel L, Dusek +2 more
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Inherited desmosomal disorders
Cell and Tissue Research, 2014Desmosomes serve as intercellular junctions in various tissues including the skin and the heart where they play a crucial role in cell-cell adhesion, signalling and differentiation. The desmosomes connect the cell surface to the keratin cytoskeleton and are composed of a transmembranal part consisting mainly of desmosomal cadherins, armadillo proteins ...
Liat, Samuelov, Eli, Sprecher
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Structural studies on desmosomes
Biochemical Society Transactions, 2008Desmosomes are cadherin-based intercellular junctions that primarily provide mechanical stability to tissues such as epithelia and cardiac muscle. Desmosomal cadherins, which are Ca2+-dependent adhesion molecules, are of central importance in mediating direct intercellular interaction.
Ashraf, Al-Amoudi +1 more
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Cell Communication & Adhesion, 2014
Desmosomes are intercellular junctions that provide strong adhesion or hyper-adhesion in tissues. Here, we discuss the molecular and structural basis of this with particular reference to the desmosomal cadherins (DCs), their isoforms and evolution. We also assess the role of DCs as regulators of epithelial differentiation.
Mohamed, Berika, David, Garrod
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Desmosomes are intercellular junctions that provide strong adhesion or hyper-adhesion in tissues. Here, we discuss the molecular and structural basis of this with particular reference to the desmosomal cadherins (DCs), their isoforms and evolution. We also assess the role of DCs as regulators of epithelial differentiation.
Mohamed, Berika, David, Garrod
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Hereditary diseases of desmosomes
Journal of Dermatological Science, 1999Desmosomes are key adhesion complexes in most epithelia, including epidermis. Although structural components of desmosomes have been identified as target antigens in several of the autoimmune blistering skin diseases, there are relatively few data on inherited disorders arising from mutations in genes encoding these proteins and glycoproteins.
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Structure and Function of Desmosomes
2007Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic intermediate filament cytoskeleton providing mechanical stability in epithelia and also in several nonepithelial tissues such as cardiac muscle and meninges. They are unique in terms of ultrastructural appearance and molecular composition with cell type-specific ...
Bastian, Holthöfer +3 more
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Inherited disorders of desmosomes
Australasian Journal of Dermatology, 2005SUMMARYDesmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. These cell–cell adhesion junctions are found in skin, heart, lymph nodes and meninges.
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