Results 61 to 70 of about 13,508 (185)

FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization

European Journal of Immunology, Volume 56, Issue 1, January 2026.
Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double‐negative thymocyte proliferation and T‐cell production.
Betul Melike Ogan, Veronika Forstlova, Laura Jane Dowling, Michaela Simova, Kristina Vicikova, Vendula Novosadova, Frantisek Spoutil, Sylvie Cervenkova, Michaela Procházková, Jolana Tureckova, Olha Fedosieieva, Juraj Labaj, Petr Nickl, Kamila Krizova, Jan Prochazka, Radislav Sedlacek, Jana Balounova   +16 more
wiley   +1 more source

Human Lysozyme Transgenic Maize Improves Colonic Inflammation by Inhibiting the cGAS/STING Signaling Pathway in DSS‐Induced Colitis Mice

Food Frontiers, Volume 7, Issue 1, January 2026.
Human lysozyme (HLZ) possesses the function of ameliorating intestinal inflammation. HLZ transgenic maize restored intestinal barrier function in colitis mice. HLZ‐feed inhibited the cGAS/STING signaling pathway by ameliorating DSS‐induced mitochondrial dysfunction.
Yinuo Yu, Yaqin Li, Xuan Chen, Rentao Song, Zhenyi Qiao, Weiwei Qi   +5 more
wiley   +1 more source

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

Small Methods, Volume 10, Issue 2, 22 January 2026.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz, Nima Pourafzal, Audrey T. Zhu, Zhongyuan Guo, Ronnie H. Fang, Liangfang Zhang   +5 more
wiley   +1 more source

Incorporation of desmocollin‐2 into the plasma membrane requires N‐glycosylation at multiple sites

FEBS Open Bio, 2019
Desmocollin‐2 (DSC2) is a desmosomal protein of the cadherin family. Desmosomes are multiprotein complexes, which are involved in cell adhesion of cardiomyocytes and of keratinocytes.
Andreas Brodehl, Caroline Stanasiuk, Dario Anselmetti, Jan Gummert, Hendrik Milting   +4 more
doaj   +1 more source

Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction

The FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.
We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen, Miki Aho, Zoltan Szabo, Johanna Magga, Laura Vainio, Erhe Gao, Paul Janmey, Lauri Eklund, Karolina Rasi, Ilkka Miinalainen, Lynn Y. Sakai, Lasse Pakanen, Heikki Huikuri, Juhani Junttila, Risto Kerkelä, Taina Pihlajaniemi   +15 more
wiley   +1 more source

Desmosomes:  Essential contributors to an integrated intercellular junction network [version 1; peer review: 2 approved]

F1000Research, 2019
The development of adhesive connections between cells was critical for the evolution of multicellularity and for organizing cells into complex organs with discrete compartments. Four types of intercellular junction are present in vertebrates: desmosomes,
Kathleen J Green, Avinash Jaiganesh, Joshua A Broussard   +2 more
doaj   +1 more source

SWI/SNF Chromatin Remodelling Complex in Hepatic Physiology: Mechanistic Insights Into Development, Homeostasis and Pathogenesis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT The liver executes essential metabolic functions including energy homeostasis, lipid biosynthesis, cholesterol regulation and xenobiotic detoxification. While hepatocyte metabolic activity forms the foundation of these processes, their precise regulation is achieved through chromatin remodelling mechanisms, with the SWI/SNF complex emerging as
Rui Li, Bo Zhang, Xinyu Wei, Jiayin Yang, Yongjie Zhou   +4 more
wiley   +1 more source

Anatomy of a bioengineered human pigmented skin equivalent to provide fundamental insights into skin tone melanin dynamics

Journal of Anatomy, Volume 248, Issue 1, Page 108-125, January 2026.
Human pigmented skin equivalents can be created in vitro to resemble alternative skin tones. Such models can be used to study skin pigmentation processes, structural changes and defined patterns among different skin tones, which correlate with the diversity of pigmentation in native skin.
Paola De Los Santos Gomez, Ranjit Rai, Pamela Ritchie, Lucy Smith, Amy Simpson, Kirsty Goncalves, Stefan Przyborski   +6 more
wiley   +1 more source

660–808 nm simultaneous irradiation enhance keratinocyte migration and change the keratin expression: An in vitro study

Photochemistry and Photobiology, Volume 102, Issue 1, Page 154-162, January/February 2026.
Exposure to both 660 and 808 nm wavelengths at the same time induced intense keratinocyte migration and altered keratin expression, indicating a potential enhancement of a subset of less‐differentiated keratinocytes. Abstract This in vitro study aimed to determine if simultaneous irradiation with 660 and 808 nm wavelengths enhances keratinocyte ...
Renan Carrasco Zuffo, Anaeliza Figueiredo dos Santos, Luciana Corrêa   +2 more
wiley   +1 more source

Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus

Frontiers in Immunology, 2018
Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes
Franziska Vielmuth, Volker Spindler, Jens Waschke   +2 more
doaj   +1 more source