Results 61 to 70 of about 12,732 (174)
FASEB BioAdvances, Volume 8, Issue 3, March 2026.This study analyzed the paracellular permeability of the intestines of healthy mice at a basal level. A new detection method involving tissue incubation for 5 min with luminal fluorescent dyes, such as FM1‐43FX (FM), which bind to accessible plasma (or external) cell membranes, was developed.
Mathilde Miquel +10 more
wiley +1 more source
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus
Nature Communications, 2023 Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament ...
Anna M. Sigmund +19 more
doaj +1 more source
Effective Management of Recalcitrant Hailey–Hailey Disease With Risankizumab
International Journal of Dermatology, EarlyView.
Joy Justice +3 more
wiley +1 more source
GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis
Animal Genetics, Volume 57, Issue 1, February 2026.Abstract Palmoplantar keratoderma in humans is a condition defined by an abnormally thickened cornified skin layer on the hands and feet. In animals, the corresponding disease is commonly termed paw pad hyperkeratosis. It can be acquired due to repeated trauma, infections, cancer, or inflammatory dermatoses, or inherited due to pathogenic variants in ...
Stefan J. Rietmann +3 more
wiley +1 more source
Desmosome assembly, homeostasis, and desmosomal disease
Cell Health and Cytoskeleton, 2016 Nicola Cirillo1,2 1Melbourne Dental School and Oral Health CRC, The University of Melbourne, Melbourne, VIC, Australia; 2Research Unit, Centre for Innovation, Research, Education, and Health (IRIS), Caposele, Italy Abstract: Cell–cell adhesion is involved in all aspects of tissue behavior in multicellular organisms, from tissue morphogenesis
openaire +4 more sources
Health Science Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari +5 more
wiley +1 more source
Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin
Frontiers in Immunology, 2019 Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
Dyah A. M. Oktarina +5 more
doaj +1 more source
Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk
The Journal of Dermatology, Volume 53, Issue 2, Page 188-199, February 2026.ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley +1 more source
Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
Allergy, Volume 81, Issue 2, Page 480-497, February 2026.This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino +12 more
wiley +1 more source
Journal of the Formosan Medical Association, 2008 Background/Purpose: Desmosome gene mutations have been reported in patients with arrhythmogenic right ventricular dysplasia (ARVD). However, there are hardly any genetic studies in Asians.
Chih-Chieh Yu +7 more
doaj +1 more source