Results 1 to 10 of about 4,329 (200)

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

Proceedings of the National Academy of Sciences, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +7 more sources

Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies [PDF]

Brazilian Journal of Medical and Biological Research, 2012
Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial.
S.H. Kasmas, M.C. Izar, C.N. França, S.C. Ramos, F.T. Moreira, T. Helfenstein, R.A. Moreno, N.C. Borges, A.M. Figueiredo-Neto, F.A. Fonseca   +9 more
doaj   +5 more sources

Basis for rapid efflux of biosynthetic desmosterol from cells [PDF]

Journal of Lipid Research, 1998
Previous work shows that the efflux of biosynthetic desmosterol from cells is three times more efficient than that of cholesterol. To explain this difference, we labeled CHO-K1 cells with [3H]acetate precursor and measured sterols in the whole cells ...
Jane Ellen Phillips, Wendi V. Rodrigueza, William J. Johnson   +2 more
doaj   +3 more sources

Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases [PDF]

Metabolites
Although the brain comprises only 2% of total body weight, it contains approximately 23% of the total cholesterol of the body. In the brain, cholesterol plays a critical role as a structural component of cell membranes and myelin sheaths.
Yoshimitsu Kiriyama, Akira Nakatsuma, Hiroshi Tokumaru, Hisayo Sadamoto, Hiromi Nochi   +4 more
doaj   +2 more sources

DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice [PDF]

iScience
Summary: The liver X receptor (LXR) is considered a therapeutic target for atherosclerosis treatment, but synthetic LXR agonists generally also cause hepatic steatosis and hypertriglyceridemia.
Xiaoke Ge, Bram Slütter, Joost M. Lambooij, Enchen Zhou, Zhixiong Ying, Ceren Agirman, Marieke Heijink, Antoine Rimbert, Bruno Guigas, Johan Kuiper, Christoph Müller, Franz Bracher, Martin Giera, Sander Kooijman, Patrick C.N. Rensen, Yanan Wang, Milena Schönke   +16 more
doaj   +2 more sources

Oxygenation of desmosterol and cholesterol in cell cultures.

Journal of Lipid Research, 1990
In order to determine whether hydration of the delta 24 bond of desmosterol contributes to the formation of the regulatory oxysterol, 25-hydroxycholesterol, [3H]desmosterol was incubated with two cultured cell lines and the labeled products were analyzed.
SE Saucier, AA Kandutsch, AK Gayen, JA Nelson, TA Spencer   +4 more
doaj   +3 more sources

Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models [PDF]

Biomolecules
Smith–Lemli–Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC).
Zeljka Korade, Allison C. Anderson, Marta Balog, Keri A. Tallman, Ned A. Porter, Karoly Mirnics   +5 more
doaj   +2 more sources

Desmosterol Incorporation Into Ram Sperm Membrane Before Cryopreservation Improves in vitro and in vivo Fertility

Frontiers in Cell and Developmental Biology, 2021
Pregnancy rates in ewes are markedly low after cervical insemination with frozen-thawed sperm. Sensitivity of ram sperm to freeze-thawing is related to the lipid composition of the membrane, particularly to its low sterol content.
María de las Mercedes Carro, Rafael R. A. Ramírez-Vasquez, Daniel A. Peñalva, Daniel A. Peñalva, Jorgelina Buschiazzo, Federico A. Hozbor   +5 more
doaj   +1 more source

Characterisation of a desmosterol reductase involved in phytosterol dealkylation in the silkworm, Bombyx mori. [PDF]

PLoS ONE, 2011
Most species of invertebrate animals cannot synthesise sterols de novo and many that feed on plants dealkylate phytosterols (mostly C(29) and C(28)) yielding cholesterol (C(27)). The final step of this dealkylation pathway involves desmosterol reductase (
Leonora F Ciufo, Patricia A Murray, Anu Thompson, Daniel J Rigden, Huw H Rees   +4 more
doaj   +1 more source

Desmosterol in Human Nonalcoholic Steatohepatitis [PDF]

Hepatology, 2013
Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH.
Kaminska Dorota, Gylling Helena Kristiin, Kuusisto Johanna, Pihlajamäki Jussi, Laakso Markku, Simonen Marko, Käkelä Pirjo, Kärjä Vesa Juhani, Männistö Ville, Gylling Helena, Pihlajamäki Jussi, Kuusisto Maria, Laakso Markku, Simonen Marko, Käkelä Pirjo, Venesmaa Sari, Kärjä Vesa, Männistö Ville, Gylling Helena, Gylling Helena   +19 more
openaire   +2 more sources