Results 11 to 20 of about 4,329 (200)

Pollen sterols are highly diverse but phylogenetically conserved. [PDF]

New Phytol
Summary Phytosterols regulate cell membrane fluidity and are precursors for plant hormones and secondary metabolites in plants. Insects are auxotrophic for sterols; therefore, they have to consume phytosterols and dealkylate them to cholesterol. Some insects, including bees, which rely on dietary sources, primarily pollen, for sterols, cannot modify ...
Baker EC, Lamborn E, Quiñonez J, Karlsdottir S, Sheppard A, Moore E, Kunin WE, Wright GA, Stevenson PC.   +8 more
europepmc   +3 more sources

In vitro metabolomics approaches to decipher the biochemical and cellular response to genotoxic compounds. [PDF]

EFSA J
Abstract New approach methodologies (NAMs) are gaining increasing attention within the scientific community as strategies to reduce the use of animal testing. Their integration into regulatory frameworks for chemical hazard and risk assessment in food and feed would directly support the goals of the European Food Safety Authority (EFSA).
Amaro F, Siniscalchi E, Varalda GM, Azzinnari E, Pinto J, de Pinho PG, Iorio E, Marcon F.   +7 more
europepmc   +2 more sources

Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket, Gryllus bimaculatus

Insects, 2021
Arthropods, including insects, convert sterols into cholesterol due to the inability to synthesise cholesterol de novo. 24-dehydrocholesterol reductase (DHCR24) plays an important role in the conversion. Not only involving the cholesterol biosynthesis in
Yin Shan Isa Mack, Masatoshi Dehari, Nobukatsu Morooka, Shinji Nagata   +3 more
doaj   +1 more source

Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]

, 2020
Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela, d’Ippolito, Giuliana, Fontana, Angelo, GALLO, CARMELA, LANDI, SIMONE, MANZO, EMILIANO, Nuzzo, Genoveffa, Sardo &   +7 more
core   +1 more source

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2008
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R., Lütjohann, Dieter, Hamid, Penny, Velasquez, Zahady D., Kerner, Katharina, Larrazabal, Camilo, Failing, Klaus, Hermosilla, Carlos, Taubert, Anja   +8 more
core   +2 more sources

Generation and validation of a conditional knockout mouse model for desmosterolosis

Journal of Lipid Research, 2021
: The enzyme 3β-hydroxysterol-Δ24 reductase (DHCR24, EC 1.3.1.72) catalyzes the conversion of desmosterol to cholesterol and is obligatory for post-squalene cholesterol synthesis.
Babunageswararao Kanuri, Vincent Fong, Sithara Raju Ponny, Ranjuna Weerasekera, Kirthi Pulakanti, Kriya S. Patel, Roman Tyshynsky, Shailendra B. Patel   +7 more
doaj   +1 more source

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism [PDF]

, 2020
Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Angelini, Roberto, Baumert, Mark, Clench, Malcolm, Griffiths, William J., Howell, Owain W., Mast, Natalia, Newton, Jillian, Pikuleva, Irina, Skibinski, David O.F., Wang, Yuqin, Yutuc, Eylan   +10 more
core   +2 more sources

Desmosterol accumulation in users of amiodarone [PDF]

Journal of Internal Medicine, 2017
AbstractBackgroundAmiodarone is an effective and widely used antiarrhythmic drug with many possible adverse effects including hypercholesterolaemia and hepatotoxicity.ObjectiveOur aim was to evaluate how long‐term amiodarone treatment affects cholesterol metabolism.MethodsThe study population consisted of 56 cardiac patients, of whom 20 were on ...
Lampi A. -M., Gylling H., Lehtonen J., Kupari M., Simonen P., Stenman U. -H., Piironen V., Lampi A. -M., Gylling H., Lehtonen J., Kupari M., Simonen P., Stenman U. -H., Piironen V.   +13 more
openaire   +2 more sources

Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]

Cell Journal, 2023
Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh   +8 more
doaj   +1 more source

Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology

Journal of Lipid Research, 2012
We performed unbiased analysis of steroid-related compounds to identify novel Alzheimer's disease (AD) plasma biomarkers using liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy.
Yoshiaki Sato, Ikumi Suzuki, Tatsuji Nakamura, Francois Bernier, Ken Aoshima, Yoshiya Oda   +5 more
doaj   +1 more source