Results 21 to 30 of about 4,329 (200)
Desmosterol Accumulation in Rats with Experimental Myotonia [PDF]
Clinical Chemistry and Laboratory Medicine, 1975 Desmosterol is found in various organs of rats that show signs of myotonia in their skeletal muscle as a result of treatment with 20.25-diazacholesterol. The amount of desmosterol depends on the time of treatment, and is different in different organs and different kinds of muscle.
Seiler, D., Fiehn, W., Kuhn, E.
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Desmosterol May Replace Cholesterol in Lipid Membranes [PDF]
Biophysical Journal, 2005 Recently, knockout mice entirely lacking cholesterol have been described as showing only a mild phenotype. For these animals, synthesis of cholesterol was interrupted at the level of its immediate precursor, desmosterol. Since cholesterol is a major and essential constituent of mammalian cellular membranes, we asked whether cholesterol with its ...
Huster, Daniel +4 more
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Tissue distribution of cholesterol and 24-dehydrocholesterol during chronic triparanol therapy
Journal of Lipid Research, 1965 The tissues of five patients who died following 4–31 months of continuous oral triparanol therapy have been analyzed for sterol content by gas–liquid chromatographic techniques.
Aram V. Chobanian, William Hollander
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Desmosterol Deposition in Human and Experimental Atherosclerosis [PDF]
Circulation Research, 1963 The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition.
J H, HERNDON, M D, SIPERSTEIN
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Journal of Lipid Research, 1963 The administration of triparanol resulted in an increase in serum total sterols and desmosterol in both cockerels and egg-laying pullets. In cockerels treated for 20 weeks with 25.0 mg of triparanol/kg body weight, the total serum sterol level was 106 mg/
Harry Y.C. Wong +4 more
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Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice
Biomolecules, 2022 De novo sterol synthesis is a critical homeostatic mechanism in the brain that begins during early embryonic development and continues throughout life.
Luke B. Allen, Károly Mirnics
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Journal of Lipid Research, 2022 Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited.
Marta Balog +4 more
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Effects of seaweed sterols fucosterol and desmosterol on lipid membranes [PDF]
, 2017 Higher sterols are universally present in large amounts (20–30%) in the plasma membranes of all eukaryotes whereas they are universally absent in prokaryotes. It is remarkable that each kingdom of the eukaryotes has chosen, during the course of evolution,
Bagatolli, Luis A. +5 more
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Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm1
Journal of Lipid Research, 1998 Previously we demonstrated high concentrations of desmosterol and docosahexaenoic acid (DHA, 22:6 n–
William E. Connor +3 more
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Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]
, 2019 Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F. +3 more
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