Journal of Lipid Research, 2015 Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate ...
Winnie Luu +3 more
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Current trends in oxysterol research [PDF]
, 2016 In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius +54 more
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Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders [PDF]
, 2014 Desmosterolosis is an autosomal recessive disorder of cholesterol biosynthesis caused by biallelic mutations of DHCR24 (homozygous or compound heterozygous), which encodes 3-β-hydroxysterol Δ-24-reductase. We report two sisters homozygous for the 571G>
Benjamin Millar +7 more
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Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid.
Journal of Lipid Research, 1993 Spermatozoa represent a tissue readily accessible for study after various exogenous perturbations. To characterize the lipid composition of monkey sperm and to establish a baseline from which dietary or pharmaceutical influences may then be evaluated, we
DS Lin +4 more
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Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis
Journal of Lipid Research, 2002 Triparanol, an inhibitor of desmosterol Δ24 reductase, produces a high rate of limb malformations in rat fetuses exposed at gestational day 10 (gd 10) to a single oral dose (150–200 mg/kg) given to the pregnant dam.
Françoise Chevy +3 more
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Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
EMBO Molecular Medicine, 2023 Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models.
Enchen Zhou +16 more
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Frontiers in Nutrition, 2022 Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes +8 more
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Cholesterol metabolism and weight reduction in subjects with mild obstructive sleep apnoea: a randomised, controlled study [PDF]
, 2013 Peer ...
Gylling, Helena +7 more
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Pathway of cholesterol biosynthesis in the brain of the neonatal rat
Journal of Lipid Research, 1966 Suckling rats were killed at various intervals after intraperitoneal injection of acetate-1-14C and their brain sterols were analyzed by column, thin-layer, paper, and gas-liquid chromatography.
Thomas J. Holstein +2 more
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Olfactomedin1 (Olfm1) in fallopian tube may modulate tubal ectopic pregnancy in humans: evidence from Immunohistochemistry and an in vitro coculture model [PDF]
, 2010 Conference Theme: The Intersection Between Genetics, Genomics, and Reproductive BiologyOlfactomedins are secretary glycoprotein constituted in the extracellular matrix (ECM) of various cell types.
Ho, PC +3 more
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