Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide-Dependent Methyltransferases Using Unactivated Methyl Donors. [PDF]
Angew Chem Int Ed EnglMixed MtaABC/MtgABC methyltransferase systems were developed for non‐native thiol and aniline methylation using the unactivated methyl donors methanol and glycine betaine. The platform enabled site‐selective and enantioselective methylation with turnover number up to 6000, representing the first enantioselective non‐native catalysis by cobamide ...
Kumar A, Adam OI, Gupta P, Lewis JC.
europepmc +3 more sources
Direct Access to Chiral Piperidines by Enantioselective HAT-Initiated C(sp<sup>3</sup>)─H Oxidation. [PDF]
Angew Chem Int Ed EnglThe direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Muthuramalingam S +5 more
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Organocatalyzed enantioselective desymmetrization of aziridines and epoxides [PDF]
Beilstein Journal of Organic Chemistry, 2013 Enantioselective desymmetrization of meso-aziridines and meso-epoxides with various nucleophiles by organocatalysis has emerged as a cutting-edge approach in recent years.
Ping-An Wang
doaj +3 more sources
Enantioselective desymmetrization strategy of prochiral 1,3-diols in natural product synthesis [PDF]
Beilstein Journal of Organic ChemistryEnantioselective desymmetrization is employed as a powerful tool for the creation of chiral centers. Within this scope, the enantioselective desymmetrization of prochiral 1,3-diols, which generates chiral centers by enantioselective functionalization of ...
Lihua Wei +3 more
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Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization [PDF]
Advanced ScienceWe report the first NHC‐catalyzed atroposelective synthesis of axially chiral tetraarylethenes (TAEs) via oxidative desymmetrization of prochiral TAE dialdehydes.
Yang‐Ze Zheng +6 more
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Strain and Chirality: Catalytic Asymmetric Synthesis of Planar Chiral [2.2]Paracyclophanes
ChemistryEuropePlanar‐chiral [2.2]paracyclophanes occupy a distinctive position in modern chemistry because their rigid cofacial aromatic architecture connects molecular shape, through‐space electronic communication and chirality within a compact scaffold.
Daniel Alonso +2 more
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Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes [PDF]
Advanced ScienceBicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules. We report a one‐step, highly enantioselective and diastereoselective reductive protocol for the synthesis of oxa‐ and
Subhankar Pradhan +5 more
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Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450BM3 [PDF]
Nature CommunicationsRiley oxidation is a powerful method for introducing oxygen functionality but typically relies on toxic reagents and generally lacks enantiocontrol. This limitation has historically restricted the utility of this transformation for the direct asymmetric ...
Yaoyao Xu +4 more
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Synthesis of chiral germanium center enabled by poly-deborylative alkylation and desymmetrization [PDF]
Nature CommunicationsChiral germanium centers are historically undervalued due to their extremely limited synthetic accessibility. Although germanium shares similar chemical properties with silicon, synthesizing chiral germanium centers proves significantly more challenging.
Ke Wang, Xin-Yuan Liu, Zhe Dong
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Palladium-catalyzed enantioselective dienylation of propargylic carbonates via sulfonimidamide desymmetrization [PDF]
Nature CommunicationsAsymmetric transition metal-catalyzed nucleophilic substitution of propargylic electrophiles is a powerful method for furnishing enantiomerically enriched molecules.
Changyu Xu +6 more
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