Results 11 to 20 of about 1,974 (174)

SIMETRIA MOLECULAR E REAçõES DE DESSIMETRIZAçãO EM SíNTESE ORGâNICA

Química Nova, 2021
MOLECULAR SYMMETRY AND DESYMMETRIZATION REACTIONS IN ORGANIC SYNTHESIS. Molecular Symmetry has found several applications in Organic Chemistry. The aim of this article is to showcase its relevance as a tool for synthetic planning.
Bruno Matos Paz, Emilio C. de Lucca Júnior, Ronaldo A. Pilli   +2 more
doaj   +1 more source

Atroposelective desymmetrization of 2-arylresorcinols via Tsuji-Trost allylation

Communications Chemistry, 2023
Desymmetrization of symmetric biaryls is an efficient but underexplored way to approach axially chiral molecules. Here, the authors report the atroposelective desymmetrization of 2- arylresorcinols via chiral palladium complex-catalyzed allylic ...
Sangji Kim, Aram Kim, Chanhee Lee, Junsoo Moon, Eun Jeong Hong, Duck-Hyung Lee, Yongseok Kwon   +6 more
doaj   +1 more source

Microbial Synthesis of (S)- and (R)-Benzoin in Enantioselective Desymmetrization and Deracemization Catalyzed by Aureobasidium pullulans Included in the Blossom Protect™ Agent

Molecules, 2021
In this study, we examined the Aureobasidium pullulans strains DSM 14940 and DSM 14941 included in the Blossom Protect™ agent to be used in the bioreduction reaction of a symmetrical dicarbonyl compound.
Renata Kołodziejska, Renata Studzińska, Agnieszka Tafelska-Kaczmarek, Hanna Pawluk, Dominika Mlicka, Alina Woźniak   +5 more
doaj   +1 more source

Desymmetrization of pibrentasvir for efficient prodrug synthesis [PDF]

Chemical Science, 2021
Horeau principle statistical amplification and solubility-driven selectivities allow C 2 -desymmetrization of pibrentasvir without typically required internal functionalization or steric proximity effects.
Eric A. Voight, Stephen N. Greszler, John Hartung, Jianguo Ji, Russell C. Klix, John T. Randolph, Bhadra H. Shelat, Jan E. Waters, David A. DeGoey   +8 more
openaire   +3 more sources

Cutinase ACut2 from Blastobotrysraffinosifermentans for the Selective Desymmetrization of the Symmetric Diester Diethyl Adipate to the Monoester Monoethyl Adipate

Microorganisms, 2022
Monoethyl adipate (MEA) is a highly valuable monoester for activating resistance mechanisms and improving protective effects in pathogen-attacked plants.
Marion Rauter, Daniela Nietz, Gotthard Kunze   +2 more
doaj   +1 more source

Diastereoselective Formal 1,3-Dipolar Cycloaddition of Trifluoroethyl Amine-Derived Ketimines Enables the Desymmetrization of Cyclopentenediones

Molecules, 2023
In this research, a metal-free diastereoselective formal 1,3-dipolar cycloaddition of N-2,2,2-trifluoroethylisatin ketimines and cyclopentene-1,3-diones which can efficiently lead to the desymmetrization of cyclopentene-1,3-diones is developed.
Lin-Qiang Li, Jian-Qiang Zhao, Yan-Ping Zhang, Yong You, Zhen-Hua Wang, Zhen-Zhen Ge, Ming-Qiang Zhou, Wei-Cheng Yuan   +7 more
doaj   +1 more source

Organocatalytic asymmetric synthesis of P-stereogenic molecules

Frontiers in Chemistry, 2023
P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems.
Junyang Liu, Junyang Liu, Hang Chen, Min Wang, Wangjin He, Jia-Lei Yan   +5 more
doaj   +1 more source

Desymmetrization of Prochiral N-Pyrazolyl Maleimides via Organocatalyzed Asymmetric Michael Addition with Pyrazolones: Construction of Tri-N-Heterocyclic Scaffolds Bearing Both Central and Axial Chirality

Molecules, 2023
The desymmetrization of N-pyrazolyl maleimides was realized through an asymmetric Michael addition by using pyrazolones under mild conditions, leading to the formation of a tri-N-heterocyclic pyrazole–succinimide–pyrazolone assembly in high yields with ...
Jianqi Geng, Xingfu Wei, Biru He, Yuting Hao, Jingping Qu, Baomin Wang   +5 more
doaj   +1 more source

Enantioselective Desymmetrization of FTY720

Chemical and Pharmaceutical Bulletin, 2014
A method for enantioselective desymmetrization of N-Ac and N-Boc-FTY720 by nonenzymatic asymmetric acylation was developed. Effective enantioselective monobenzoylation using benzoyl chloride in the presence of the tetraphenylbisoxazoline (L2)-CuCl2 complex gave the desired products 3a and 3b in 52-62% yield with 64% ee.
Hikawa, Hidemasa, Hamada, Maiko, Uchida, Yuka, Kikkawa, Shoko, Yokoyama, Yuusaku, Azumaya, Isao   +5 more
openaire   +3 more sources

Biomimetic Desymmetrization of a Carboxylic Acid [PDF]

Journal of the American Chemical Society, 2018
The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization.
Matthew T. Knowe, Michael W. Danneman, Sarah Sun, Maren Pink, Jeffrey N. Johnston   +4 more
openaire   +2 more sources