Results 31 to 40 of about 1,974 (174)

Enzymatic Desymmetrization of Prochiral Molecules

Current Organic Synthesis, 2012
josempalomo@icp.csic.es; zaida.cabrera@ucv ...
Palomo, Jose M., Cabrera, Zaida
openaire   +3 more sources

Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides

Advanced Science, EarlyView.
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan, Shengzhou Jin, Zhao‐Dong Xu, Guigen Li, Dingyi Wang   +4 more
wiley   +1 more source

Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition

Beilstein Journal of Organic Chemistry, 2017
We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones.
Matthew A. Horwitz, Elisabetta Massolo, Jeffrey S. Johnson   +2 more
doaj   +1 more source

Bicarbonate-binding catalysis for the enantioselective desymmetrization of keto sulfonium salts

Nature Communications
Herein, an enantioselective desymmetrization of cyclic keto sulfonium salts through enantioselective deprotonation/ring opening process by anion-binding catalysis is presented.
José Alemán, Jorge Humbrías-Martín, Roberto del Río-Rodríguez, Fernando Aguilar-Galindo, Sergio Díaz-Tendero, Jose A. Fernández-Salas   +5 more
doaj   +1 more source

Asymmetric desymmetrization of meso-diols by C2-symmetric chiral 4-pyrrolidinopyridines

Beilstein Journal of Organic Chemistry, 2012
In this work we developed C2-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective ...
Hartmut Schedel, Keizo Kan, Yoshihiro Ueda, Kenji Mishiro, Keisuke Yoshida, Takumi Furuta, Takeo Kawabata   +6 more
doaj   +1 more source

The application of desymmetric enantioselective reduction of cyclic 1,3-dicarbonyl compounds in the total synthesis of terpenoid and alkaloid natural products

Beilstein Journal of Organic Chemistry
The desymmetric enantioselective reduction of cyclic 1,3-dicarbonyl compounds is a powerful tool for the construction of ring systems bearing multiple stereocenters including all-carbon quaternary stereocenters, which are widely useful chiral building ...
Dong-Xing Tan, Fu-She Han
doaj   +1 more source

Stereoselective Synthesis of Fluoroalkanes via FLP Mediated Monoselective C─F Activation of Geminal Difluoroalkanes

Advanced Science, 2023
A method of desymmetrization of geminal difluoroalkanes using frustrated Lewis pair (FLP) mediated monoselective C–F activation where a chiral sulfide is the Lewis base component is reported. The stereoselective reaction provides generally high yields of
Dániel Csókás, Bivas Mondal, Miloš Đokić, Richa Gupta, Beatrice J. Y. Lee, Rowan D. Young   +5 more
doaj   +1 more source

desymmetrization

, 2014
Citation: 'desymmetrization' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.D01623 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Helical Single Crystals of Porous Hydrogen‐Bonded Organic Frameworks as a Candidate for Morphologically Functional Organic Materials

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Helical‐shaped crystals of a hydrogen‐bonded organic framework (HOF) with permanent porosity have been developed. The helical HOF shows expansion and contraction, respectively, upon desorption and adsorption of solvents. Moreover, doping of additive molecules can modulate the photophysical properties and morphology of the helical HOF, showing the ...
Yuzuki Murata, Taito Hashimoto, Ryusei Oketani, Miki Naruoka, Yuuya Nagata, Ryosuke Tamura, Masayuki Morimoto, Mio Yamashita, Daisuke Sakamaki, Norimitsu Tohnai, Hitoshi Asakawa, Ichiro Hisaki   +11 more
wiley   +2 more sources

NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

Nature Communications, 2019
Axially chiral biaryl amino-alcohols play a pivotal role in organic synthesis and drug discovery. Here, the authors report a cooperative strategy consisting of desymmetrization followed by kinetic resolution to deliver non-classical NOBIN derivatives in ...
Gongming Yang, Donghui Guo, Di Meng, Jian Wang   +3 more
doaj   +1 more source