Results 101 to 110 of about 10,823 (192)

Targeting deubiquitinating enzymes in cancer: navigating context-dependence for precision medicine

Oncologie
The ubiquitin-proteasome system (UPS) is a master regulator of protein homeostasis, and its dysregulation is a well-established driver of oncogenesis, metastasis, and therapeutic resistance.
Khamjan Nizar A.
doaj   +1 more source

CMA‐mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Deubiquitinase USP9X suppresses SHH Medulloblastoma progression by facilitating SUFU ubiquitination. SHH promotes USP9X degradation through the CMA pathway. Combined inhibition of CMA and SHH pathway had a synergically therapeutic effect on SHH Medulloblastoma.
Binbin Gao, Qin Zhu, Lun Kuang, Jiahui Li, Qingyue Meng, Bo'ang Han, Yu Wang, Xinyi Zhang, Xiangxiang Zhang, Xinfa Wang, Tingting Yu, Shen Yue, Chen Liu   +12 more
wiley   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

The impact of scaRNA12 deregulation on p53‐mediated cellular stress response in B‐cell precursor acute lymphoblastic leukaemia

British Journal of Haematology, Volume 208, Issue 3, Page 883-896, March 2026.
Summary Small nucleolar ribonucleic acids (snoRNAs) are a class of small non‐coding RNAs involved in the post‐transcriptional modification of ribosomal RNAs (rRNA) and small nuclear RNAs (snRNA). Mounting evidence indicates that specific snoRNAs are drivers of oncogenesis, but their role in B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) is ...
Martijn W. C. Verbeek, Mathijs A. Sanders, Dwin G. B. Grashof, Remco M. Hoogenboezem, Iris van Zuijen, Annemarieke Bos, Trui van Gulck, Rosan Olsman, Rishov Mukhopadhyay, Eric M. J. Bindels, Peter J. M. Valk, Harmen J. G. van de Werken, Vincent H. J. van der Velden, Stefan J. Erkeland   +13 more
wiley   +1 more source

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes. [PDF]

Front Immunol, 2023
Wehrmann M, Vilchez D.
europepmc   +1 more source

PSMD12 Overexpression Promotes Lung Adenocarcinoma Progression via Ubiquitin–Proteasome Pathway Dysregulation

Cancer Science, Volume 117, Issue 3, Page 644-656, March 2026.
PSMD12, located on the frequently amplified 17q region in LUAD, is upregulated in tumors and associated with poor prognosis and advanced stage. Functional studies revealed that PSMD12 promotes cell proliferation and G2/M transition by inhibiting CDK1 ubiquitination and stabilizing CDK1.
Yuya Ono, Hajime Otsu, Takaaki Masuda, Keisuke Kosai, Shohei Shibuta, Kosuke Hirose, Takashi Ofuchi, Yuki Ando, Koto Kawata, Yasuo Tsuda, Yusuke Yonemura, Taro Tobo, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Koshi Mimori   +14 more
wiley   +1 more source

Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma. [PDF]

Genes (Basel), 2023
Min Y, Park HB, Baek KH, Hwang S.
europepmc   +1 more source

ApCtf1β‐Interacting Target Proteins BDPH1 and BDEUL12 Regulate Pathogenicity in Arthrinium phaeospermum

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
This study found that BDPH1 and BDEUL12 interact with Apctf1β. They regulate growth, development, and chemical stress response in Arthrinium phaeospermum, and are crucial for its pathogenicity. ABSTRACT Arthrinium phaeospermum is the primary pathogen responsible for shoot blight disease in Bambusa pervariabilis × Dendrocalamopsis grandis.
Qian Chen, Haiyan Luo, Han Zhao, Zhanbo Liu, Shan Han, Chunlin Yang, Long Liu, Hua Yang, Han Liu, Shujiang Li   +9 more
wiley   +1 more source

Research Status of Deubiquitinating Enzymes and JOSD2 in Malignant Tumors

Zhongliu Fangzhi Yanjiu
Ubiquitination is a crucial post-translational modification process that can degrade proteins within cells and plays a vital role in maintaining protein homeostasis and abundance.
WANG Wenpeng, SHI Dan, YUN Duo, KONG Dalu, WANG Jiefu   +4 more
doaj   +1 more source