Results 41 to 50 of about 538,441 (213)
Deubiquitinating enzymes regulate PARK2-mediated mitophagy. [PDF]
, 2015 The selective degradation of mitochondria by the process of autophagy, termed mitophagy, is one of the major mechanisms of mitochondrial quality control. The best-studied mitophagy pathway is the one mediated by PINK1 and PARK2/Parkin.
Kim, Peter K +7 more
core +1 more source
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]
, 2014 Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
Virdee, Satpal; id_orcid +15 more
core +1 more source
Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity
Journal of Neuroinflammation, 2020 Multiple sclerosis (MS) is the most common autoimmune disease of the CNS. The etiology of MS is still unclear but it is widely recognized that both genetic and environmental factors contribute to its pathogenesis.
Jing Ruan, Dirk Schlüter, Xu Wang
doaj +1 more source
Systematic analysis of the physiological importance of deubiquitinating enzymes. [PDF]
PLoS ONE, 2012 Deubiquitinating enzymes (DUBs) are proteases that control the post-translational modification of proteins by ubiquitin and in turn regulate diverse cellular pathways.
Wei-Ling Tsou +6 more
doaj +1 more source
MdmX is a substrate for the deubiquitinating enzyme USP2a [PDF]
Oncogene, 2009 It has previously been shown that ubiquitin-specific protease 2a (USP2a) is a regulator of the Mdm2/p53 pathway. USP2a binds to Mdm2 and can deubiquitinate Mdm2 without reversing Mdm2-mediated p53 ubiquitination. Overexpression of USP2a causes accumulation of Mdm2 and promotes p53 degradation. We now show that MdmX is also a substrate for USP2a.
Allende-Vega, N. +3 more
openaire +3 more sources
Writing and erasing MYC ubiquitination and SUMOylation
Genes and Diseases, 2019 The transcription factor c-MYC (MYC thereafter) controls diverse transcription programs and plays a key role in the development of many human cancers. Cells develop multiple mechanisms to ensure that MYC levels and activity are precisely controlled in ...
Yingxiao Chen +3 more
doaj +1 more source
Protease addiction and synthetic lethality in cancer
Frontiers in Oncology, 2011 The oncogene addiction concept refers to the dependence of cancer cells on the function of the oncogenes responsible for their transformed phenotype, while the term non-oncogene addiction has been introduced to define the exacerbated necessity of the ...
Jose M.P. Freije +2 more
doaj +1 more source
Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code
Frontiers in Pharmacology, 2021 Post-translational modifications such as ubiquitination play important regulatory roles in several biological processes in eukaryotes. This process could be reversed by deubiquitinating enzymes (DUBs), which remove conjugated ubiquitin molecules from ...
Yanfeng Wang, Feng Wang
doaj +1 more source
Nature Communications, 2021 Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating ...
Jinxiu Hou +9 more
doaj +1 more source
Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases
Frontiers in Cell and Developmental Biology, 2021 The balance of ubiquitination and deubiquitination plays diverse roles in regulating protein stability and cellular homeostasis. Deubiquitinating enzymes catalyze the hydrolysis and removal of ubiquitin chains from target proteins and play critical roles
Wenjing Zhu +6 more
doaj +1 more source