Viral deubiquitinating proteases and the promising strategies of their inhibition [PDF]
Virus ResearchSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling ...
Vera J.E. van Vliet +3 more
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Deubiquitinating Enzymes: Their Functions and Substrate Specificity
Current Protein and Peptide Science, 2004 Conjugation of one or more molecules of ubiquitin to target proteins can signify one of several fates, including degradation by the 26S proteasome, or trafficking via the secretory or endocytic pathways. Whereas much attention in recent years has focussed on the mechanisms of forming these different ubiquitin conjugates, far less is known about the ...
Soboleva, Tatiana, Baker, Rohan
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Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma. [PDF]
Genes (Basel), 2023 In ovarian cancer patients, the 5-year survival rate is 90% for stages I and II, but only 30% for stages III and IV. Unfortunately, as 75% of the patients are diagnosed at stages III and IV, many experience a recurrence.
Min Y, Park HB, Baek KH, Hwang S.
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L'Enzim deubiqüitinant USP25: cerca de substrats i relació estructura-funció [PDF]
, 2007 [cat] La degradació de proteïnes mitjançant el sistema de les ubiquitines i el proteasoma (UPS) és un procés altament regulat, en el qual diverses famílies enzimàtiques s'encarreguen de la correcte conjugació i deconjugació de molècules d'ubiquitina a un
Bosch Comas, Anna
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Deubiquitinating Enzyme Inhibitors and their Potential in Cancer Therapy
Current Cancer Drug Targets, 2014 Deubiquitinating enzymes (or DUBs) attack the ubiquitin-based isopeptide bond, thus counteracting ubiquitinprotein ligase activity in vivo. By disassembling ubiquitin-substrate and ubiquitin-ubiquitin covalent links, deubiquitinating enzymes exert a very powerful control of many signaling processes within the ubiquitin-proteasome system (UPS).
Crosas, Bernat
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Role of E3 ubiquitin ligases and deubiquitinating enzymes in SARS-CoV-2 infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Chunlan Zhang +2 more
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Targeting Deubiquitinating Enzymes (DUBs) That Regulate Mitophagy via Direct or Indirect Interaction with Parkin [PDF]
International Journal of Molecular Sciences, 2022 Robin Ketteler
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Inhibitors of Deubiquitinating Enzymes Interfere with the SARS-CoV-2 Papain-like Protease and Block Virus Replication In Vitro [PDF]
Viruses, 2022 Vladimir Temchura +2 more
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Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans. [PDF]
PLoS ONE, 2012 Ubiquitination is a reversible protein modification that influences various cellular processes in eukaryotic cells. Deubiquitinating enzymes remove ubiquitin, maintain ubiquitin homeostasis and regulate protein degradation via the ubiquitination pathway.
Wei Fang +8 more
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Advances in deubiquitinating enzymes in lung adenocarcinoma. [PDF]
J Cancer, 2021 The process of ubiquitination and deubiquitination is widely present in the human body's protein reactions and plays versatile roles in multiple diseases. Deubiquitinating enzymes (DUBs) are significant regulators of this process, which cleave the ubiquitin (Ub) moiety from various substrates and maintain protein stability.
Zhou XJ, Li R, Liu X, Qu YQ.
europepmc +4 more sources