Results 31 to 40 of about 538,441 (213)

Protein partners of deubiquitinating enzymes [PDF]

Biochemical Journal, 2008
Protein modification by ubiquitin and ubiquitin-like molecules is a critical regulatory process. Like most regulated protein modifications, ubiquitination is reversible. Deubiquitination, the reversal of ubiquitination, is quickly being recognized as an important regulatory strategy.
Karen H, Ventii, Keith D, Wilkinson
openaire   +2 more sources

Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation. [PDF]

PLoS ONE, 2015
Although protein ubiquitination has been shown to regulate multiple processes during host response to Salmonella enterica serovar Typhimurium infection, specific functions of host deubiquitinating enzymes remain unknown in this bacterial infection.
Evangel Kummari, Navatha Alugubelly, Chuan-Yu Hsu, Brittany Dong, Bindu Nanduri, Mariola J Edelmann   +5 more
doaj   +1 more source

A Novel Type of Deubiquitinating Enzyme [PDF]

Journal of Biological Chemistry, 2003
A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-kappaB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R., and Kilshaw, P. J. (2001) Biochem. J. 357, 617-623).
Paul C, Evans, Trevor S, Smith, Meng-Jiun, Lai, Mark G, Williams, David F, Burke, Karen, Heyninck, Marja M, Kreike, Rudi, Beyaert, Tom L, Blundell, Peter J, Kilshaw   +9 more
openaire   +2 more sources

Deubiquitinating Enzymes as Therapeutic Candidates in Hepatocellular Carcinoma and Other Liver Disease. [PDF]

Int J Mol Sci
Hepatocellular carcinoma is challenging to detect at an early stage, and its severity increases over time. Recently, the incidence of hepatocellular carcinoma has increased, partly due to lifestyle-related factors such as excessive alcohol intake ...
Jeong YH, Lee HH, Kim YJ, Lee HR, Lim KH.   +4 more
europepmc   +2 more sources

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes. [PDF]

Front Immunol, 2023
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and ...
Wehrmann M, Vilchez D.
europepmc   +2 more sources

Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery

Frontiers in Chemistry, 2020
The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making its tight regulation key to ...
Neil C. Taylor, Joanna F. McGouran
doaj   +1 more source

A Review on Deubiquitinating Enzymes as Oncodiagnostic Biomarkers

, 2023
Cancer is a fatal illness that is responsible for the deaths of millions of individuals all over the globe every year. It is possible that people will be able to survive for a longer period of time as a result of early identification, staging, and ...
Shobhit Raj
core   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +2 more sources

Enzymes of ubiquitination and deubiquitination

Essays in Biochemistry, 2012
Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by mediating the regulated degradation of proteins. Aside from proteasomal degradation, ubiquitination plays important roles in transcriptional regulation, protein trafficking, including endocytosis and ...
Neutzner, M., Neutzner, A.
openaire   +4 more sources

Functional annotation of deubiquitinating enzymes using RNA interference. [PDF]

, 2005
Protein ubiquitination is a dynamic process, depending on a tightly regulated balance between the activity of ubiquitin ligases and their antagonists, the ubiquitin-specific proteases or deubiquitinating enzymes.
Nijman, S.M.B., Brummelkamp, T.R., Annette M.G. Dirac, Dirac, A.M.G., Nijman, SM, Thijn R. Brummelkamp, Bernards, R.A., Sebastian M.B. Nijman, René Bernards, Dirac, AM, Nijman, Sebastian, Bernards, R, Brummelkamp, TR   +12 more
core   +1 more source