Results 11 to 20 of about 538,441 (213)
A Method for Assaying Deubiquitinating Enzymes [PDF]
Biological Procedures Online, 1998 A general method for the assay of deubiquitinating enzymes was described in detail using 125I-labeled ubiquitin-fused &agr;NH-MHISPPEPESEEEEEHYC (referred to as Ub-PESTc) as a substrate.
Lee Jae Il +6 more
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Deubiquitinating enzymes as oncotargets [PDF]
Oncotarget, 2015 Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics.
McClurg UL, Robson CN
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Deubiquitinating Enzymes and Bone Remodeling [PDF]
Stem Cells International, 2018 Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling ...
Yu-chen Guo, Shi-wen Zhang, Quan Yuan
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Mechanism and function of deubiquitinating enzymes [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004 Attachment of ubiquitin to proteins is a crucial step in many cellular regulatory mechanisms and contributes to numerous biological processes, including embryonic development, the cell cycle, growth control, and prevention of neurodegeneration. In these diverse regulatory settings, the most widespread mechanism of ubiquitin action is probably in the ...
Amerik, Alexander Y., Hochstrasser, Mark
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The role of deubiquitinating enzymes in spermatogenesis
Cellular and Molecular Life Sciences, 2015 Spermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which ...
Bharathi, Suresh +4 more
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Role of Deubiquitinating Enzymes in DNA Repair [PDF]
Molecular and Cellular Biology, 2016 Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate
Kee, Younghoon, Huang, Tony T.
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Deubiquitinating enzymes at the crossroads of lipid metabolism and cancer [PDF]
Journal of Biological Research - Thessaloniki, 2021 Deregulated lipid metabolism has been recognized as a critical alteration that supports the development and growth of various types of tumors. Changes in lipid metabolism enable reprogramming of energetics and availability of synthetic intermediates and ...
Christos Gonidas +2 more
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Deubiquitinating Enzymes: A Critical Regulator of Mitosis [PDF]
International Journal of Molecular Sciences, 2019 Mitosis is a complex and dynamic process that is tightly regulated by a large number of mitotic proteins. Dysregulation of these proteins can generate daughter cells that exhibit genomic instability and aneuploidy, and such cells can transform into tumorigenic cells. Thus, it is important for faithful mitotic progression to regulate mitotic proteins at
Jinyoung Park +3 more
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Targeting deubiquitinating enzymes in cancer stem cells
Cancer Cell International, 2017 Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation ...
Hu Lei, Huizhuang Shan, Yingli Wu
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UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes [PDF]
Journal of Biological Chemistry, 2009 A balance between ubiquitination and deubiquitination regulates numerous cellular processes and pathways, and specific deubiquitinating enzymes often play the decisive role of controlling this balance. We recently reported that the USP1 deubiquitinating enzyme, which regulates the Fanconi anemia pathway by deubiquitinating the central player of the ...
Cohn, Martin A. +4 more
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