Results 81 to 90 of about 10,823 (192)

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, EarlyView.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

USP18 mediates high glucose‐induced cardiomyocyte injury by regulating the JAK/STAT signaling pathway through stabilizing FOXC2 expression

Journal of Diabetes Investigation, EarlyView.
USP18 upregulation stabilizes FOXC2 expression by deubiquitination to inactivate the JAK2/STAT3 pathway, thereby inhibiting HG‐induced NMVM apoptosis, inflammation, oxidative stress, and fibrosis. ABSTRACT Background Cardiomyopathy is one of the complications of diabetes, among which myocardial fibrosis is the most typical feature.
Zhengrong Xu, Weidong Ren, Jun Gu, Wenjuan Deng, Lijuan Zuo   +4 more
wiley   +1 more source

The role of the ubiquitin-proteasome system in the development of acute myocardial injury. Case report

Терапевтический архив
Background. Acute myocardial injury (AMI) is a universal pathological process that complicates both cardiac and non-cardiac pathologies. However, understanding of the molecular mechanisms underlying the various types of AMI remains insufficient.
Dmitry A. Kudlay, Vadim V. Tarasov, Elena A. Smolyarchuk, Vlas S. Shchekin, Ksenia A Zavadich, Vladislav I. Korunas, Irina D. Krylova, Aleksandr V. Samorodov   +7 more
doaj   +1 more source

The ZmCOP1s–ZmCOL3 Module Enhances Late Flowering, Grain Yield and Grain Quality in Maize

Plant Biotechnology Journal, EarlyView.
ABSTRACT Flowering time is a key determinant of yield and regional adaptation in crops and is largely controlled by light signalling. In this study, we identified two maize orthologs of Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), designated ZmCOP1a and ZmCOP1b, which activate light signalling and reduce plant height. Loss‐of‐function mutants of
Shuling Yang, Yanpei Zhang, Lianhua Cui, Weimin Zhan, Shizhan Chen, Yu Zhang, Haolei Han, Linhu Song, Longchao Du, Kangni Zhang, Huan Liu, Shaoci Wang, Yong Shi, Jihua Tang, Xiangguo Liu, Jianping Yang   +15 more
wiley   +1 more source

Structure and Function of Viral Deubiquitinating Enzymes

Journal of Molecular Biology, 2017
Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes, including innate and adaptive immune responses. Ubiquitin-mediated control over these processes can be reversed by cellular deubiquitinating enzymes (DUBs), which remove ubiquitin from cellular targets and depolymerize polyubiquitin chains.
Bailey-Elkin, B.A., Knaap, R.C.M., Kikkert, M., Mark, B.L.   +3 more
openaire   +3 more sources

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

Nature Communications, 2019
TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ...
Xin Wu, Caoqi Lei, Tian Xia, Xuan Zhong, Qing Yang, Hong-Bing Shu   +5 more
doaj   +1 more source

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics

Frontiers in Chemistry, 2019
Enzymes that bind and process ubiquitin, a small 76-amino-acid protein, have been recognized as pharmacological targets in oncology, immunological disorders, and neurodegeneration.
Adán Pinto-Fernández, Adán Pinto-Fernández, Simon Davis, Simon Davis, Abigail B. Schofield, Abigail B. Schofield, Hannah C. Scott, Hannah C. Scott, Ping Zhang, Ping Zhang, Eidarus Salah, Eidarus Salah, Eidarus Salah, Sebastian Mathea, Sebastian Mathea, Philip D. Charles, Philip D. Charles, Andreas Damianou, Andreas Damianou, Gareth Bond, Gareth Bond, Roman Fischer, Roman Fischer, Benedikt M. Kessler, Benedikt M. Kessler   +24 more
doaj   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, EarlyView.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

Hypoxic and Fe‐Responses are Regulated by the ERFVII Factors and the PCO Branch of the N‐Degron Pathway According to Iron Availability

Plant, Cell &Environment, EarlyView.
ABSTRACT In plants, iron homeostasis and oxygen metabolism are strictly related, indeed several Fe‐requiring enzymes catalyze reactions that also involve O2 as a reagent, product, entry or end point of the pathway. Oxygen sensing itself relies on the Fe‐dependent enzymes Plant cysteine oxidases.
Yuri Telara, Moez Maghrebi, Mikel Lavilla‐Puerta, Noemi La Monaca, Giulia Ambrogini, Alessio Sbrana, Sara Delucchi, Pierdomenico Perata, Gianpiero Vigani, Beatrice Giuntoli   +9 more
wiley   +1 more source

Deubiquitinating enzymes for targeted cancer therapy

Clinical and Translational Discovery, 2023
Yue Li, Xiaohui Wang
doaj   +1 more source