UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2 [PDF]
eLife, 2020 Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the latent peptidases DA1,
Hannes Vanhaeren +10 more
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Ubiquitination and deubiquitination as critical modulators of NSCLC tumorigenesis and drug resistance [PDF]
Discover OncologyUbiquitination and deubiquitination are biological mechanisms that including the addition and removal ubiquitin molecules from proteins, which are associated with NSCLC.
Prasanna Srinivasan Ramalingam +12 more
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The role of USP36 in ribosome biogenesis and other pathophysiological processes [PDF]
Frontiers in Molecular BiosciencesUbiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis.
Linxin Shao +5 more
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Translational Oncology, 2023 Aberrant expression of deubiquitinases (DUBs) is significantly associated with tumorigenesis. However, the precise impact of deubiquitination on the tumour microenvironment (TME) and immunotherapy in hepatocellular carcinoma (HCC) remains unclear.
Jiahao Zhang +10 more
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Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
Heliyon, 2023 This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats.
Shu-wen Jin +3 more
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Deubiquitinating Enzymes in Parkinson’s Disease [PDF]
Frontiers in Physiology, 2020 La disfunción mitocondrial y la neurodegeneración se han correlacionado directamente en muchos trastornos neurodegenerativos. La enfermedad de Parkinson (EP) en particular se ha estudiado ampliamente en este contexto debido a su asociación bien caracterizada con la mitofagia, un tipo selectivo de autofagia que degrada las mitocondrias.
Joy Chakraborty, Elena Ziviani
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Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex. [PDF]
PLoS ONE, 2017 Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes ...
Hainan Zheng +7 more
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Frontiers in Oncology, 2023 Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC.
Yiyang Sun, Ping He, Li Li, Xue Ding
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Emerging role of deubiquitination modifications of programmed death-ligand 1 in cancer immunotherapy
Frontiers in Immunology, 2023 Immune evasion is essential for carcinogenesis and cancer progression. Programmed death-ligand 1 (PD-L1), a critical immune checkpoint molecule, interacts with programmed death receptor-1 (PD-1) on immune cells to suppress anti-tumor immune responses. In
Yao Jiang +5 more
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Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
Microbiology Spectrum, 2021 Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 ...
Akshaya Ramachandran +3 more
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