Results 21 to 30 of about 27,539 (236)
USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]
, 2017 Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza +6 more
core +1 more source
ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
Frontiers in Cell and Developmental Biology, 2020 DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 ...
Winnie Tan +5 more
doaj +1 more source
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Cellular & Molecular Biology Letters, 2022 Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia +7 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2022 Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain and disability among many affected individuals. However, the current treatments for IVDD are limited to relieving the symptoms but do not solve the fundamental ...
Hai Bao +8 more
doaj +1 more source
The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. [PDF]
, 2017 Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7).
Garza, Renee M +6 more
core +2 more sources
Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]
, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Jarmoszewicz, Katarzyna +3 more
core +4 more sources
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1 [PDF]
, 2018 The Fanconi anemia pathway for DNA interstrand crosslink repair and the translesion synthesis pathway for DNA damage tolerance both require cycles of monoubiquitination and deubiquitination.
Arkinson, Connor +3 more
core +3 more sources
Deubiquitinating enzymes as oncotargets
Oncotarget, 2015 Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics.
McClurg UL, Robson CN
openaire +4 more sources
Protein partners of deubiquitinating enzymes [PDF]
Biochemical Journal, 2008 Protein modification by ubiquitin and ubiquitin-like molecules is a critical regulatory process. Like most regulated protein modifications, ubiquitination is reversible. Deubiquitination, the reversal of ubiquitination, is quickly being recognized as an important regulatory strategy.
Karen H, Ventii, Keith D, Wilkinson
openaire +2 more sources
Cezanne regulates E2F1-dependent HIF2α expression [PDF]
, 2015 Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Altun +48 more
core +4 more sources