Results 31 to 40 of about 27,539 (236)
Nature Communications, 2019 In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical ...
Fengshan Liang +9 more
doaj +1 more source
Deubiquitinating Function of Adenovirus Proteinase [PDF]
Journal of Virology, 2002 ABSTRACT The invasion strategy of many viruses involves the synthesis of viral gene products that mimic the functions of the cellular proteins and thus interfere with the key cellular processes. Here we show that adenovirus infection is accompanied by an increased ubiquitin-cleaving (deubiquitinating) activity in the host cells.
Maxim Y, Balakirev +3 more
openaire +2 more sources
USP7: Novel Drug Target in Cancer Therapy
Frontiers in Pharmacology, 2019 Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation.
Zhiru Wang +15 more
doaj +1 more source
The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer
Frontiers in Endocrinology, 2023 The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway.
Zhen Ye +4 more
doaj +1 more source
echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases [PDF]
, 2007 Background: Programmed cell death is used to remove excess cells between ommatidia in the Drosophila pupal retina. This death is required to establish the crystalline, hexagonal packing of ommatidia that characterizes the adult fly eye.
Bosdet, Ian +5 more
core +4 more sources
Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex? [PDF]
, 2013 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.Peer ...
Donaldson, Anne D +2 more
core +1 more source
Deubiquitinating Enzymes and Bone Remodeling [PDF]
Stem Cells International, 2018 Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in ...
Yu-chen Guo, Shi-wen Zhang, Quan Yuan
openaire +3 more sources
Assay Systems for Profiling Deubiquitinating Activity [PDF]
International Journal of Molecular Sciences, 2020 Deubiquitinating enzymes regulate various cellular processes, particularly protein degradation, localization, and protein–protein interactions. The dysregulation of deubiquitinating enzyme (DUB) activity has been linked to several diseases; however, the function of many DUBs has not been identified.
Jinhong Cho +3 more
openaire +2 more sources
Ubiquitination and Deubiquitination in Oral Disease [PDF]
International Journal of Molecular Sciences, 2021 Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed ...
Tsuchida, Sachio, Nakayama, Tomohiro
openaire +2 more sources
Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway [PDF]
, 2007 Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the understanding of the cellular events involved in NF-kB induction.
Boris Cvek +5 more
core +2 more sources