Results 31 to 40 of about 145,903 (280)

The developmental profile of visual cortex astrocytes

iScience, 2023
Summary: We investigated how astrocytes in layer 5 mouse visual cortex mature over postnatal days (P) 3–50. Across this age range, resting membrane potential increased, input resistance decreased, and membrane responses became more passive with age.
Airi Watanabe, Connie Guo, Per Jesper Sjöström   +2 more
doaj   +1 more source

16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis

iScience, 2022
Summary: The complex 16p11.2 deletion syndrome (16pdel) is accompanied by neurological disorders, including epilepsy, autism spectrum disorder, and intellectual disability. We demonstrated that 16pdel iPSC differentiated neurons from affected people show
Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour, Jasmine M. McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H. Futerman, Hazel Sive   +7 more
doaj   +1 more source

Theoretical Models of Neural Development

iScience, 2018
Constructing a functioning nervous system requires the precise orchestration of a vast array of mechanical, molecular, and neural-activity-dependent cues.
Geoffrey J. Goodhill
doaj   +1 more source

Development and cadherin-mediated control of prefrontal corticostriatal projections in mice

iScience, 2023
Summary: Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developing ...
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson   +11 more
doaj   +1 more source

Aberrant cortical projections to amygdala GABAergic neurons contribute to developmental circuit dysfunction following early life stress

iScience, 2023
Summary: Early life stress (ELS) results in enduring dysfunction of the corticolimbic circuitry, underlying emotional and social behavior. However, the neurobiological mechanisms involved remain elusive.
Joni Haikonen, Jonas Englund, Shyrley Paola Amarilla, Zoia Kharybina, Alexandra Shintyapina, Kristel Kegler, Marta Saez Garcia, Tsvetomira Atanasova, Tomi Taira, Henrike Hartung, Sari E. Lauri   +10 more
doaj   +1 more source

Resting-state fMRI and developmental systems neuroscience [PDF]

Frontiers in Neuroscience, 2011
Lucina Q Uddin
doaj   +3 more sources

Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain

iScience, 2022
Summary: After demyelinating insult, the neuronal progenitors of the adult mouse sub-ventricular zone (SVZ) called neuroblasts convert into oligodendrocytes that participate to the remyelination process.
Bilal El Waly, Claire Bertet, Mathilde Paris, Marie Falque, Pierre Milpied, Karine Magalon, Myriam Cayre, Pascale Durbec   +7 more
doaj   +1 more source

Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood

iScience, 2021
Summary: In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender   +7 more
doaj   +1 more source

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

iScience, 2020
Summary: Mammalian brain development critically depends on proper thyroid hormone signaling, via the TRα1 nuclear receptor. The downstream mechanisms by which TRα1 impacts brain development are currently unknown. In order to investigate these mechanisms,
Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant   +6 more
doaj   +1 more source

KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner

iScience, 2022
Summary: A growing body of human literature implicates KIBRA in memory and neurodevelopmental disorders. Memory and the cellular substrates supporting adaptive cognition change across development.
Matthew L. Mendoza, Lilyana D. Quigley, Thomas Dunham, Lenora J. Volk   +3 more
doaj   +1 more source