Results 91 to 100 of about 63,586 (320)

Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis

Anaesthesia, EarlyView.
Summary Introduction Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta‐analysis of randomised controlled trials assessing the effect of pharmacological interventions on the ...
Ivo Queiroz, Lucas M. Barbosa, Mariano Gallo Ruelas, Beatriz Araújo, Maria L. R. Defante, Arthur H. Tavares, Cynthia Florencio de Mesquita, Tulio Pimentel, Beatriz Ximenes Mendes, Iuri Ferreira Felix, André Rivera, Rafael Oliva Morgado Ferreira, Helen M. de Oliveira, Bruno B. Righetto, Nathan J. Smischney, Guangyu Tong, Daqing Ma   +16 more
wiley   +1 more source

Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial

Chinese Medical Journal, 2019
Background: Postoperative cognitive dysfunction (POCD) is a serious complication after surgery, especially in elderly patients. The anesthesia technique is a potentially modifiable risk factor for POCD. This study assessed the effects of dexmedetomidine,
Wei-xia Li, Ruyi Luo, Chao Chen, Xiang Li, Jing-sheng Ao, Yue Liu, Yiqing Yin   +6 more
semanticscholar   +1 more source

Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice

Anesthesiology, 2020
Background: Clinical studies have shown that dexmedetomidine ameliorates cognitive decline in both the postoperative and critical care settings. This study determined the mechanism(s) for the benefit provided by dexmedetomidine in a medical illness in ...
Rong Li, I. K. Lai, Jonathan Z. Pan, Pengbo Zhang, M. Maze   +4 more
semanticscholar   +1 more source

Dexmedetomidine in the Supratentorial Craniotomy

The Eurasian Journal of Medicine, 2010
In this double-blind prospective clinical study, we investigated the effects of fentanyl and dexmedetomidine as adjuvant agents in supratentorial craniotomies on the following: hemodynamic changes during perioperative and recovery periods, brain edema perioperatively, recovery times and side effects, such as hypertension, shivering, nausea and vomiting.
Senem Koruk, Osman Ilhan, Gokcen Serin, Ibrahim Erkutlu, Unsal Oner   +4 more
openaire   +3 more sources

Postoperative sore throat: a systematic review*

Anaesthesia, EarlyView.
Summary Introduction Postoperative sore throat is a common complaint with an incidence of up to 62%. While anaesthetists often perceive this as a minor and self‐limiting complication, postoperative sore throat is one of the leading causes of postoperative anaesthesia‐related discomfort.
Zachary J. Moulder, Jason Mann, Paul Bramley, Jana Heinz, Matthew D. Wiles   +4 more
wiley   +1 more source

Analgesia for Thoracic Surgery: Does Intraoperative Methadone Deserve a Place?

ANZ Journal of Surgery, EarlyView.
Intraoperative methadone: potential benefits and considerations for thoracic surgery analgesia.
Eugene Constantine Lai, William Thomas Birkett, Luxmana Jeganathan, Ashley St John, Anurag Vijay, Walston Reginald Martis   +5 more
wiley   +1 more source

The Effect of Dexmedetomidine on Emergence Agitation or Delirium in Children After Anesthesia—A Systematic Review and Meta-Analysis of Clinical Studies

Frontiers in Pediatrics, 2020
Background: We conducted this systematic review and meta-analysis to investigate the clinical effect of dexmedetomidine in preventing pediatric emergence agitation (EA) or delirium (ED) following anesthesia compared with placebo or other sedatives ...
Y. Rao, R. Zeng, Xuebin Jiang, Jun Li, Xiao-cou Wang   +4 more
semanticscholar   +1 more source

Exploring the Therapeutic Potential of MIR‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies

Cell Proliferation, EarlyView.
Global landscape. ABSTRACT Osteoarthritis (OA) is a prevalent and debilitating joint disorder that affects millions of individuals worldwide, severely impairing mobility, independence, and quality of life. Emerging evidence suggests that ferroptosis is a critical factor in OA pathogenesis.
Feng Ma, Lexin Wang, Hao Chi, Xinyi Li, Yaoqin Xu, Kexin Chen, Jingfan Zhou, Runqin Yang, Jie Liu, Ke Xu, Xiaoling Yang   +10 more
wiley   +1 more source

41. The myocardial protective effect of dexmedetomidine in high risk patients undergoing aortic vascular surgery

Journal of the Saudi Heart Association, 2016
Dexmedetomidine provides perioperative cardiac protection in high risk patients assessment the effect of dexmedetomidine in high risk patients undergoing aortic vascular surgery. Arandomized study included 150 patients classified into two groups(n = 75).
R. Soliman
doaj   +1 more source

Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

Anesthesiology, 2020
Background: Dexmedetomidine induces a sedative response that is associated with rapid arousal. To elucidate the underlying mechanisms, the authors hypothesized that dexmedetomidine increases the activity of dopaminergic neurons in the ventral tegmental ...
Gaolin Qiu, Ying Wu, Zeyong Yang, Long Li, Xiao-na Zhu, Yiqiao Wang, Wenzhi Sun, Hailong Dong, Yuanhai Li, Ji Hu   +9 more
semanticscholar   +1 more source