Results 191 to 200 of about 98,007 (275)

Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Parthenolide attenuates skeletal muscle atrophy through coordinated regulation of protein homeostasis and inflammatory signaling. It counteracts TNF‐α‐mediated inhibition of AKT signaling, thereby restoring AKT–mTOR activation to promote protein synthesis and suppress protein degradation through inhibition of the FoxO transcription factors, which ...
Yu Bai   +12 more
wiley   +1 more source

ALOX15‐Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq–PLC–PKC Pathway

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ALOX15 expression and its downstream oxylipins, including 12‐HETE and 13‐HODE, are induced in intestinal epithelial and lamina propria immune cells during the early and middle phases of experimental colitis. These endogenous lipid mediators suppress lipopolysaccharide‐induced TNF‐α and IL‐6 production in macrophages without affecting cell viability ...
Adrian Hilman   +4 more
wiley   +1 more source

Regional and Sex‐Dependent Immune Profiling Across the Colon in A Mouse Model of Ulcerative Colitis

open access: yesThe FASEB Journal, Volume 40, Issue 5, 15 March 2026.
At baseline, males have higher IL‐10, TH17 cytokines, and higher macrophages, neutrophils, and CD8+ cells in the medial and distal colon. Whereas females displayed increasing macrophages, lower TNF‐α, and higher IL‐1β, IL‐17A, and dendritic cells in the cecum and proximal colon.
Diane M. Tshikudi   +6 more
wiley   +1 more source

Targeting metallothionein in dextran sulfate sodium-induced colitis points to new therapeutic strategies for patients suffering from inflammatory bowel diseases [PDF]

open access: yes, 2012
Cuvelier, Claude   +7 more
core   +1 more source

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