, 2018 Ulcerative colitis (UC), with a long course and repeated attack, severely affects patient's life quality and increases economic burden all over the world. However, the concrete causes and mechanisms of UC are still unclear, but it is generally considered
Shiying Wang (5179559) +8 more
core +1 more source
Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2 0-deoxyguanosine, in rat colonic mucosa [PDF]
, 1998 Dextran sodium sulfate (DSS) given in drinking water can induce colonic Inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic.
Petit, Claude +5 more
core
Dextran sulfate promotes the rapid aggregation of porcine bone-marrow stromal cells
, 1995 Despite the fact that cells of the mammalian stromal compartment of bone marrow have been shown to contain multipotential stem cells when studied in diffusion chambers it is notable that the same range of possible phenotypes (e.g., chondrocytic) has not ...
N. Loveridge +3 more
core +1 more source
Lithium induces intestinothrophic effects in the healthy colon, but does not ameliorate dextran sulfate sodium-induced colitis in mice [PDF]
, 2012 Background & aims: Ulcerative colitis is characterized by severe damage of the colon epithelium. Wnt-signaling is important for repair and regeneration of the intestinal epithelium.
Blokzijl, Tjasso +8 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Antiplatelet agents’-ticagrelol and eptifibatide-safety in experimental colitis in mice
The Turkish Journal of Gastroenterology, 2020 Background/Aims: To evaluate the side effects of two antiplatelet agents - ticagrelor and eptifibatide - in mice with experimentally-induced inflammatory bowel disease. Methods and Material: This study was designed as a controlled, animal, drug safety
Stanko S. Petrovic +12 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Green Soybean Extract Ameliorates Dextran Sodium Sulfate-Induced Colitis
Natural Product Communications, 2018 Green-mature soybean ( Glycine max ) extract (GSE) inhibits the progression of immunoglobulin E-mediated inflammation more than the ordinary yellow-pigmented soybean extract (YSE).
Yuko Yoshikawa +6 more
doaj +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Neuroinflammation in the gut is associated with many gastrointestinal (GI) diseases, including inflammatory bowel disease. In the brain, neuroinflammatory conditions are associated with blood-brain barrier (BBB) disruption and ...
David Dora +10 more
doaj +1 more source