Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
core +1 more source
A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]
, 2016 © 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson +11 more
core +1 more source
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]
, 2016 Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson +27 more
core +1 more source
Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]
, 2012 Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Bauer, Christian +4 more
core +1 more source
Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis
Scientific Reports, 2021 FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and tumour development.
Tsuneyuki Miyazaki +13 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Neuroinflammation in the gut is associated with many gastrointestinal (GI) diseases, including inflammatory bowel disease. In the brain, neuroinflammatory conditions are associated with blood-brain barrier (BBB) disruption and ...
David Dora +10 more
doaj +1 more source
Amphiphile Adsorption on Rigid Polyelectrolytes
, 2007 A theory is presented which quantitatively accounts for the cooperative adsorption of cationic surfactants to anionic polyelectrolytes. For high salt concentration we find that the critical adsorption concentration (CAC) is a bilinear function of the ...
Barbosa, Marcia C. +3 more
core +1 more source
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF [PDF]
, 2013 Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases.
Albanese CT +15 more
core +3 more sources
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Green Soybean Extract Ameliorates Dextran Sodium Sulfate-Induced Colitis
Natural Product Communications, 2018 Green-mature soybean ( Glycine max ) extract (GSE) inhibits the progression of immunoglobulin E-mediated inflammation more than the ordinary yellow-pigmented soybean extract (YSE).
Yuko Yoshikawa +6 more
doaj +1 more source