Results 71 to 80 of about 78,284 (308)

Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling

Cellular and Molecular Life Sciences
Background and aims Oxysterols, oxidized derivatives of cholesterol, play complex roles in inflammatory processes, but their specific functions in inflammatory bowel diseases remain incompletely understood.
Hafsa Ameraoui, Joan Bestard-Escalas, Martin Roumain, Adam Laghouati, Pauline Bottemanne, Mireille Alhouayek, Giulio G. Muccioli   +6 more
doaj   +1 more source

Effects of Dextran Sulfate on Aprotinin Activity

Japanese Journal of Pharmacology, 1985
Dextran sulfate has an action on aprotinin activity similar to that seen with heparin: preincubation of dextran sulfate with aprotinin enhanced the inhibitory effect of aprotinin on the esterolytic activity of trypsin, but did not change the effect on the proteolytic activity of trypsin or on the esterolytic and proteolytic activities of chymotrypsin ...
openaire   +3 more sources

Anomalous decrease in dextran sulfate clearance in the diabetic rat kidney

, 1998
The anomalous increase in charge selectivity as previously observed with reduced dextran sulfate clearances in diabetic rats (L. D. Michels, M. Davidman, and W. F. Keane. Kidney Int.
Neale Cohen, Sianna Panagiotopoulos, George Jerums, Melissa J. Burne, Wayne D. Comper, Yalçin Adal   +5 more
core   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

Angewandte Chemie, EarlyView.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka, Eirini‐Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos Livas, George Froudakis, Ioannis Drygiannakis, Athina Damianaki, George Kolios, Vassilis Valatas, Nikolaos Eleftheriadis   +10 more
wiley   +2 more sources

Heparin and dextran sulfate: their role on rsv infectivity

, 2010
Respiratory syncytial virus is the major cause of acute lower respiratory tract illness in infants and young children. Because there is currently no licensed vaccine for RSV, there is a substantial interest in the identification and development of RSV ...
Durigon, Edison Luiz, Rahal, Paula, Calça, Jaqueline, Gomes, Deriane Elias, Bonfim, Caroline Measso, Rubio, Marcelo, Toledo, Karina Alves, Fossey, Marcelo Andres, Souza, Fátima Pereira de   +8 more
core   +2 more sources

Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model

, 2009
Objective: Mitogen-activated protein kinases (MAPKs), including JNK, p38, and ERK1/2, noticeably influence ischemia/reperfusion injury (IRI). The complement inhibitor dextran sulfate (DXS) associates with damaged endothelium denudated of its heparan ...
Gajanayake, Thusitha, Katja Matozan, Matozan, Katja, Robert Rieben, Rieben, Robert, Thusitha Gajanayake, Banz, Yara, Yang, Zhihong, Yara Banz, Zhihong Yang   +9 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Optimization of the in vitro Model of Cardiac Fibrosis [PDF]

Brazilian Journal of Cardiovascular Surgery
Introduction: Despite the prevalence of cardiac fibrosis, there are currently no effective treatments to reverse it. A major obstacle is the lack of reliable in vitro models.
Zeinab Neshati, Zahra Esmaeili, Farrokh Arzi   +2 more
doaj   +2 more sources