DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO‐Mediated HSP90AA1 m6A Levels
During Leydig cell senescence, decreased DNMT1 triggers Fto promoter hypomethylation and upregulates FTO. Elevated FTO reduces m6A modification of Hsp90aa1, lowering HSP90AA1 to inhibit AKT signaling, facilitate apoptosis and reduce testosterone synthesis.
Yaqi Li +8 more
wiley +1 more source
Between love and pain: A qualitative analysis of menstrual distress and romantic relationships
Abstract Menstrual distress ‐ the physiological and emotional stress response to menstrual symptoms that are perceived as threatening and difficult to manage ‐ is common among menstruating people and can have a profound negative impact on mental health and well‐being.
Theresa J. S. Wallner +2 more
wiley +1 more source
ABSTRACT Aim To examine whether self‐reported thriving at work is associated with biomarkers of stress, inflammation, neuroplasticity and neurodegeneration in nurses. Design A cross‐sectional study. Methods An online questionnaire measuring thriving at work was administered to nurses in a teaching hospital in Michigan, U.S. over 5 weeks in 2024.
Judith E. Arnetz +8 more
wiley +1 more source
Objective: Endocrine findings in premature adrenarche have been characterized by elevated dehydroepiandrosterone (DHEA) DHEA-sulfate (DHEA-S) levels in the past. Methods: We reviewed female patients, aged 4 to 8 years, with premature adrenarche who were
Liana Gabriel +5 more
doaj +1 more source
DEHYDROEPIANDROSTERONE AND ORAL GLUCOSE TOLERANCE TEST IN YOUNG WOMEN: IS IT RELATED TO EACH OTHER?
Introduction. In this study we wanted to compare the means of area under the curve (AVC) of glucose tolerance test in young women depending on dehydroepiandrosteron (DHEA) levels. Methods.
A.M AMINI, M NATEGHI, M HOSSEINPOOR
doaj
Evaluation of metabolic, reproductive, and gut microbiota alterations in a comparative study of different preclinical models of polycystic ovary syndrome. [PDF]
Khobragade NH +6 more
europepmc +1 more source
Comparing Hair Cortisol, DHEA, and Cortisol-to-DHEA Ratios from Various Body Sites in Anatolian Shelter Dogs. [PDF]
Ghassemi Nejad J, Ghanbari F, Sun SH.
europepmc +1 more source
Adrenal androgen mediates the association between obesity and accelerated skeletal maturation in children and adolescents. [PDF]
Choi Y +11 more
europepmc +1 more source
Effects of CPAP withdrawal on sex hormone levels in patients with obstructive sleep apnoea: data from two randomised, controlled trials. [PDF]
Grewe FA +8 more
europepmc +1 more source
When Good Biology Meets Negative Clinical Trials: Lessons from PHANTOM and EDIPHY. [PDF]
Lachant D, Austin E.
europepmc +1 more source

