Results 61 to 70 of about 10,008 (239)

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity [PDF]

Proceedings of the National Academy of Sciences, 1998
DHEA, together with DHEAS, is the most abundant steroid in the blood of young adult humans. Levels in humans decline with age and during certain types of illness or stress. We have found that DHEA(S) can prevent or reduce the neurotoxic actions in the hippocampus of the glutamate agonists N ...
V G, Kimonides, N H, Khatibi, C N, Svendsen, M V, Sofroniew, J, Herbert   +4 more
openaire   +2 more sources

Opioid withdrawal syndrome‐associated cognitive impairment: A narrative review

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Opioid withdrawal syndrome (OWS) comprises a transient constellation of subjective symptoms and objective signs expressed by brain and other organs. Although cognitive impairment is well documented in opioid use and addiction, little is known about cognitive impairment that may specifically accompany OWS.
Faizan Khan, Nazli Tunali, R. Andrew Chambers   +2 more
wiley   +1 more source

Effect Of Neurosteroid Dehydroepiandrosterone Sulfate (DHEAS)

, 2007
Memory is stored in the brain as unique patterns called engrams. Neurotransmitter mediated excitation of these engrams is responsible for recollection. Memory loss is a result of neuronal death due to age or disease.
Arshad, Samreen
core   +1 more source

Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study

Electronic Physician, 2018
Background: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA.
Mahin Lashkari, Akram Noori, Sonia Oveisi, Mohammadreza Kheirkhah   +3 more
doaj   +1 more source

In vivo activation of the constitutive androstane receptor β (CARβ) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA‐S) [PDF]

FEBS Letters, 2002
We investigated whether dehydroepiandrosterone (DHEA) or DHEA‐sulfate (S) affected the activities of nuclear receptors, with special reference to constitutive androstane receptor β (CARβ). Administration of DHEA or DHEA‐S enhanced the DNA binding of hepatic nuclear extracts to responsive elements for the retinoic acid receptor, the retinoic acid ...
Fujita, Atsushi, Furutama, Daisuke, Tanaka, Toshifumi, Sakai, Reiko, Koyama, Akio, Hanafusa, Toshiaki, Mitsuhashi, Tomoaki, Ohsawa, Nakaaki   +7 more
openaire   +2 more sources

The Association of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate with Obesity, Waist-hip Ratio, and Insulin Resistance in Postmenopausal Women

Endocrinology Research and Practice, 2022
Recent studies revealed that oral dehydroepiandrosterone (DHEA) reduced weight gain in genetically obese mice without affecting their food intake. We aimed to compare the association of DHEA and dehydroepiandrosterone sulfate (DHEAS) levels with obesity,
Murat Saruç, Bilgin Özmen, Bülent Kılıççıoğlu   +2 more
doaj   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

The DHEAS-Induced Enhancement of Hippocampal Primed Burst Potentiation is Blocked by Psychological Stress

, 1999
This series of studies investigated the effects of psychological stress and the neurosteroid dehydroepiandrosterone sulfate (DHEAS) on hippocampal primed burst (PB) and long-term (LTP) potentiation, two electrophysiological models of memory.
Fleshner, Monika, Rose, Gregory M., Diamond, David M.   +2 more
core   +1 more source

Neuroprotective Effects of Dehydroepiandrosterone Sulphate Against Aβ Toxicity and Accumulation in Cellular and Animal Model of Alzheimer’s Disease

Biomedicines
Background/Objectives: Beneficial effects of neurosteroid dehydroepiandrosterone sulphate (DHEAS) on cognition, emotions and behavior have been previously reported, suggesting its potential in the prevention and treatment of various neuropsychiatric and ...
Barbara Vuic, Tina Milos, Erika Kvak, Marcela Konjevod, Lucija Tudor, Szidónia Farkas, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Dora Zelena, Dubravka Svob Strac   +9 more
doaj   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source