Results 41 to 50 of about 37,090 (310)
Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report
Korean Journal of Transplantation, 2019 Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial.
Yoonhong Kim +7 more
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Advanced Science, EarlyView.This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang +15 more
wiley +1 more source
Albumin-induced apoptosis of tubular cells is modulated by BASP1 [PDF]
, 2015 Albuminuria promotes tubular injury and cell death, and is associated with faster progression of chronic kidney disease (CKD) to end-stage renal disease.
Cannata, Pablo +9 more
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Advanced Science, EarlyView.This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang +19 more
wiley +1 more source
Advanced Science, EarlyView.Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun +9 more
wiley +1 more source
Online Brazilian Journal of Nursing, 2007 This work tries to understand how a family faces the care with one of its members with diagnosis of diabetic nephropathy during dialysis treatment. This is a qualitative study, conducted by the purposes of ethnographic method, which used the Calgary ...
Gisele Fráguas, Sônia Maria Soares
doaj +2 more sources
The role of sirolimus in proteinuria in diabetic nephropathy rats [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): The aim of this study was to observe the impact of sirolimus on proteinuria in streptozotocin (STZ) induced diabetic rats. Materials and Methods: Rats were given a single injection of STZ to induce diabetic rat model.
JinJun Wang +5 more
doaj +1 more source
Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis. [PDF]
, 2014 Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood.
Chan, LYY +11 more
core +1 more source
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Protein kinase R-like endoplasmic reticulum kinase pathway and diabetic kidney disease
Linchuang shenzangbing zazhi, 2020 Endoplasmic reticulum stress is closely related to the occurrence and development of diabetic kidney disease.As an important signaling pathway induced by endoplasmic reticulum stress,protein kinase R-like endoplasmic reticulum kinase(PERK)pathway can ...
庞欣欣 +5 more
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